DSpace Collection:https://hdl.handle.net/2440/52922024-03-18T16:06:54Z2024-03-18T16:06:54ZPredicting progression of Parkinson’s disease motor outcomes using a multimodal combination of baseline clinical measures, neuroimaging and biofluid markersMcNamara, A.Ellul, B.Baetu, I.-I.Lau, S.Jenkinson, M.Collins-Praino, L.https://hdl.handle.net/2440/1402652023-12-21T02:25:10Z2023-01-01T00:00:00ZTitle: Predicting progression of Parkinson’s disease motor outcomes using a multimodal combination of baseline clinical measures, neuroimaging and biofluid markers
Author: McNamara, A.; Ellul, B.; Baetu, I.-I.; Lau, S.; Jenkinson, M.; Collins-Praino, L.
Abstract: Abstract not available
Description: Abstract #P34.112023-01-01T00:00:00ZAssociations Between Aldosterone-Renin-Ratio and Bone Parameters Derived from Peripheral Quantitative Computed Tomography and Impact Microindentation in MenHolloway-Kew, K.L.Anderson, K.B.Rufus-Membere, P.Tembo, M.C.Sui, S.X.Hyde, N.K.Kotowicz, M.A.Gwini, S.M.Yang, J.Diez-Perez, A.Henneberg, M.Liao, W.-H.Pasco, J.A.https://hdl.handle.net/2440/1395582023-11-19T01:28:54Z2023-01-01T00:00:00ZTitle: Associations Between Aldosterone-Renin-Ratio and Bone Parameters Derived from Peripheral Quantitative Computed Tomography and Impact Microindentation in Men
Author: Holloway-Kew, K.L.; Anderson, K.B.; Rufus-Membere, P.; Tembo, M.C.; Sui, S.X.; Hyde, N.K.; Kotowicz, M.A.; Gwini, S.M.; Yang, J.; Diez-Perez, A.; Henneberg, M.; Liao, W.-H.; Pasco, J.A.
Abstract: Components of the renin-angiotensin-aldosterone system (RAAS) are present on bone cells. One measure of RAAS activity, the aldosterone-renin-ratio (ARR), is used to screen for primary aldosteronism. Associations between ARR and bone mineral density are conflicting. This study investigated associations between ARR and peripheral quantitative computed tomography (pQCT) and impact microindentation (IMI). Male participants (n = 431) were from the Geelong Osteoporosis Study. "Likely" primary aldosteronism was defined as ARR ≥ 70 pmol/mIU. Another group, "possible" primary aldosteronism, was defined as either ARR ≥ 70 pmol/mIU or taking a medication that affects the RAAS, but not a beta blocker, and renin < 15 mU/L. Using pQCT, images at 4% and 66% of radial (n = 365) and tibial (n = 356) length were obtained. Using IMI measurements, bone material strength index (BMSi; n = 332) was determined. Associations between ARR or likely/possible primary aldosteronism and IMI or pQCT-derived bone parameters were tested using median regression. ARR and aldosterone values were not associated with any of the pQCT-derived bone variables in either unadjusted or adjusted analyses. Men with likely primary aldosteronism (n = 16), had lower adjusted total bone area (radial 66% site, - 12.5%). No associations were observed for men with possible primary aldosteronism (unadjusted or adjusted). No associations with BMSi were observed (p > 0.05). There were no associations between ARR or aldosterone and pQCT-derived bone parameters. Men with likely primary aldosteronism had lower bone area, suggesting clinically high levels of ARR may have a negative impact on bone health.
Description: Published online: 10 September 20232023-01-01T00:00:00ZCerebrovascular contribution to dementia development after traumatic brain injury: promises and problemsCollins-Praino, L.Corrigan, F.https://hdl.handle.net/2440/1389282023-12-20T00:41:40Z2018-01-01T00:00:00ZTitle: Cerebrovascular contribution to dementia development after traumatic brain injury: promises and problems
Author: Collins-Praino, L.; Corrigan, F.
Description: Editorial2018-01-01T00:00:00ZAge, but not severity of injury, mediates decline in executive function: validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injuryArulsamy, A.Corrigan, F.Collins-Praino, L.E.https://hdl.handle.net/2440/1295132023-12-20T00:39:35Z2019-01-01T00:00:00ZTitle: Age, but not severity of injury, mediates decline in executive function: validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injury
Author: Arulsamy, A.; Corrigan, F.; Collins-Praino, L.E.
Abstract: Increasingly, it is being recognised that traumatic brain injury (TBI) is not just an acute event but instead results in ongoing neuronal injury that may lead to chronic impairments in multiple cognitive domains. Of these, deficits in executive function are one of the more common changes reported following TBI, and are a major predictor of well-being, social function and quality of life in individuals with a history of TBI. In order to fully understand the relationship between TBI and executive dysfunction, including brain mechanisms that may account for this, experimental models are clearly needed. However, to date, there have been a lack of preclinical studies systematically comparing the effect of injury severity on executive function, particularly at long-term timepoints post-injury. Furthermore, many previous studies have not used behavioural measures that are sensitive to the full range of executive function impairments that may manifest after injury, particularly in models of diffuse axonal injury (Lv et al.). The current study aimed to investigate the temporal profile, up to 12 months post-injury, of the evolution of executive dysfunction following different severities of injury in an experimental model of DAI. In order to do so, we utilised a rodent touchscreen paradigm to administer the 5 Choice- Continuous Performance Task (5C-CPT), an extension of the 5-choice serial reaction time task (5CSRT). Interestingly, there were no differences in learning, motivation, attention, response time or impulsivity at 1 month, 6 months or 12 months post-injury in any of the TBI groups compared to sham, regardless of the initial severity of the injury. Instead, most of the effects on executive function seen at the 12 month timepoint appeared to be a result of ageing, not injury. As even the 12-month timepoint represents middle age in the rat, future studies will be needed to further probe these effects, in order to determine whether DAI may influence the presentation of executive dysfunction in older age.2019-01-01T00:00:00Z