http://hdl.handle.net/2440/74194 Thu, 25 Feb 2021 17:48:02 GMT 2021-02-25T17:48:02Z http://hdl.handle.net/2440/128998 Title: Forensic science in Ghana: A review Author: Aaron, A.; Amoako, E.; Bonsu, D.O.M.; Banyeh, M. Abstract: The use of forensic science continues to grow across the world. In Ghana, major advancements took off in 2011, including the introduction of modern DNA profiling and the establishment of an automated fingerprint identification system. These developments have led to some positive impacts on the delivery of justice, including the exoneration of a wrongly incarcerated individual. However, a review of the policy-related aspects of forensic science shows gaps in legislation, governance, service provision, quality assurance and accreditation, education and research. An important recommendation to improve forensic science in Ghana is the creation of a “national policy strategy”, a blueprint informed by relevant stakeholders, best practice from other countries and the status of the field. Resolutions to the policy issues identified in this review will ensure a more robust application of forensic science in delivering safe justice and enhancing public security. Description: Available online 30 July 2019 Tue, 01 Jan 2019 00:00:00 GMT http://hdl.handle.net/2440/128998 2019-01-01T00:00:00Z http://hdl.handle.net/2440/128997 Title: Immunotherapy for acute myeloid leukemia (AML): a potent alternative therapy Author: Acheampong, D.O.; Adokoh, C.K.; Asante, D.B.; Asiamah, E.A.; Barnie, P.A.; Bonsu, D.O.M.; Kyei, F. Abstract: The standard therapy of AML for many years has been chemotherapy with or without stem transplantation. However, there has not been any tangible improvement in this treatment beyond induction through chemotherapy and consolidation with allogeneic stem cell transplantation or chemotherapy. Residual AML cells which later cause relapse mostly persist even after rigorous standard therapy. It is imperative therefore to find an alternative therapy that can take care of the residual AML cells. With a better understanding of how the immune system works to destroy tumor cells and inhibit their growth, another therapeutic option immunotherapy has emerged to address the difficulties associated with the standard therapy. Identification of leukemia-associated antigens (LAA) and the fact that T and NK cells can be activated to exert cytotoxicity on AML cells have further introduced diverse immunotherapeutic development strategies. This review discusses the merits of current immunotherapeutic strategies such as the use of antibodies, adoptive T cells and alloreactive NK cell, and vaccination as against the standard therapy of AML. Mon, 01 Jan 2018 00:00:00 GMT http://hdl.handle.net/2440/128997 2018-01-01T00:00:00Z http://hdl.handle.net/2440/128690 Title: Preliminary ancient DNA screening results from first to eighth century AD sites in Samtavro and Tchkantiskedi, Georgia Author: Papac, L.; Llamas, B.; Cooper, A.; Pilbrow, V.; Haak, W. Abstract: Ancient DNA allows the analysis of the genetic makeup of past populations. However, due to the highly variable nature of DNA preservation it is often useful to screen samples in order to assess the quality of DNA preservation before deciding how to invest resources into further sequencing efforts. Here we present screening results of 34 human bone and teeth samples showing a high variation in DNA preservation not only across the whole cemetery but also within tombs of the same cemetery. Preliminary analyses show that preservation levels are satisfactory for genetic characterisation of this ancient population. Mon, 01 Jan 2018 00:00:00 GMT http://hdl.handle.net/2440/128690 2018-01-01T00:00:00Z http://hdl.handle.net/2440/128632 Title: Data-sharing for indigenous peoples Author: Kowal, E.; Llamas, B.; Tishkoff, S. Description: Correspondence Sun, 01 Jan 2017 00:00:00 GMT http://hdl.handle.net/2440/128632 2017-01-01T00:00:00Z