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https://hdl.handle.net/2440/10091
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Type: | Journal article |
Title: | Immunohistochemical localization of CD1 a-positive putative dendritic cells in human breast tumours |
Author: | Hillenbrand, E. Neville, A. Coventry, B. |
Citation: | British Journal of Cancer, 1999; 79(5-6):940-944 |
Publisher: | CHURCHILL LIVINGSTONE |
Issue Date: | 1999 |
ISSN: | 0007-0920 1532-1827 |
Abstract: | The presence of a high number of infiltrating CD1a+cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a+cells within the lymphoid cell infiltrate in human ductal breast carcinoma (n= 52), which was significantly different from normal breast tissue, in which only two out of nine cases expressed CD1a+cells (P= 0.0192). In the majority of cases, the infiltrate was low compared with the number of macrophages and T cells present (results not shown). There was no correlation between the number of CD1a+cells and tumour grade, with all tumour grades expressing similar numbers of infiltrating CD1a+cells. There was clear evidence, however, that the CD1a+cells were closely associated with tumour cells. It is likely that CD1a+cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a+cells in a large sample of all histological grades of human breast carcinomas. |
Keywords: | CD1a dendritic cells immunohistochemistry breast tumour human cancer |
Rights: | © 1999 Cancer Research Campaign |
DOI: | 10.1038/sj.bjc.6690150 |
Published version: | http://dx.doi.org/10.1038/sj.bjc.6690150 |
Appears in Collections: | Aurora harvest Surgery publications |
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