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https://hdl.handle.net/2440/10211
Type: | Journal article |
Title: | 5-ASA decreases colonic sulfide formation: implications for ulcerative colitis. |
Author: | Roediger, W. Duncan, A. |
Citation: | Medical science research, 1996; 24(1):27-29 |
Issue Date: | 1996 |
ISSN: | 0269-8951 |
Abstract: | Experimental evidence suggests that anionic sulfide (SH-) may be implicated in the pathogenesis of ulcerative colitis. Sulfides are formed in the colon by sulfate-reducing bacteria acting on sulfate or sulfur amino acids. Experiments were designed to test whether the most useful drug for ulcerative colitis, 5-aminosalicylic acid (5ASA) or salicylazosulfapyridine (SASP) could suppress sulfide formation from sulfur amino acids by anaerobic bacteria grown in batch culture. Neither 5-ASA or SASP altered acetate formation, a universal indicator of fermentation. Both agents very significantly reduced sulfide formation by anaerobic bacteria of the human colon grown in batch culture. Such an action of 5-ASA/SASP may reduce the injurious action of sulfide on the colonie epithelial cell barrier of the colon and help to prevent attacks of colitis. Keywords: 5-aminosalicylic acid, colon, sulfides, ulcerative colitis, fermentation. |
Appears in Collections: | Aurora harvest 7 Surgery publications |
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