Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/102566
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leong, Y. | - |
dc.contributor.author | Chen, Y. | - |
dc.contributor.author | Ong, H. | - |
dc.contributor.author | Wu, D. | - |
dc.contributor.author | Man, K. | - |
dc.contributor.author | Deleage, C. | - |
dc.contributor.author | Minnich, M. | - |
dc.contributor.author | Meckiff, B. | - |
dc.contributor.author | Wei, Y. | - |
dc.contributor.author | Hou, Z. | - |
dc.contributor.author | Zotos, D. | - |
dc.contributor.author | Fenix, K. | - |
dc.contributor.author | Atnerkar, A. | - |
dc.contributor.author | Preston, S. | - |
dc.contributor.author | Chipman, J. | - |
dc.contributor.author | Beilman, G. | - |
dc.contributor.author | Allison, C. | - |
dc.contributor.author | Sun, L. | - |
dc.contributor.author | Wang, P. | - |
dc.contributor.author | Xu, J. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Nature Immunology, 2016; 17(10):1187-1196 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.issn | 1529-2916 | - |
dc.identifier.uri | http://hdl.handle.net/2440/102566 | - |
dc.description.abstract | During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differentiation of these cells, which we have called ‘follicular cytotoxic T cells’ (TFC cells), required the transcription factors Bcl6, E2A and TCF-1 but was inhibited by the transcriptional regulators Blimp1, Id2 and Id3. Blimp1 and E2A directly regulated Cxcr5 expression and, together with Bcl6 and TCF-1, formed a transcriptional circuit that guided TFC cell development. The identification of TFC cells has far-reaching implications for the development of strategies to control infections that target B cells and TFH cells and to treat B cell–derived malignancies. | - |
dc.description.statementofresponsibility | Yew Ann Leong, Iain Comerford, Kevin A Fenix, Shaun R McColl | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2016 Nature America, Inc. All rights reserved. | - |
dc.source.uri | http://www.nature.com/ni/journal/v17/n10/full/ni.3543.html | - |
dc.subject | Germinal Center | - |
dc.subject | B-Lymphocytes | - |
dc.subject | T-Lymphocytes, Cytotoxic | - |
dc.subject | Cells, Cultured | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Mice, Transgenic | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Lymphocytic choriomeningitis virus | - |
dc.subject | HIV | - |
dc.subject | Epstein-Barr Virus Infections | - |
dc.subject | Arenaviridae Infections | - |
dc.subject | Transcription Factors | - |
dc.subject | Cell Differentiation | - |
dc.subject | Gene Expression Regulation | - |
dc.subject | Male | - |
dc.subject | Hepatocyte Nuclear Factor 1-alpha | - |
dc.subject | Proto-Oncogene Proteins c-bcl-6 | - |
dc.subject | Basic Helix-Loop-Helix Transcription Factors | - |
dc.subject | Receptors, CXCR5 | - |
dc.subject | Positive Regulatory Domain I-Binding Factor 1 | - |
dc.title | CXCR5⁺ follicular cytotoxic T cells control viral infection in B cell follicles | - |
dc.title.alternative | CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/ni.3543 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Fenix, K. [0000-0003-1619-1406] | - |
dc.identifier.orcid | McColl, S. [0000-0003-0949-4660] | - |
Appears in Collections: | Aurora harvest 3 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.