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https://hdl.handle.net/2440/10354
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Type: | Journal article |
Title: | Electrolytic liver ablation is not associated with evidence of a systemic inflammatory response syndrome |
Author: | Teague, B. Court, F. Morrison, C. Kho, M. Wemyss-Holden, S. Maddern, G. |
Citation: | British Journal of Surgery, 2004; 91(2):178-183 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2004 |
ISSN: | 0007-1323 1365-2168 |
Statement of Responsibility: | D. Teague, F.G. Court, C.P. Morrison, M. Kho, S. A. Wemyss-Holden and G.J. Maddern |
Abstract: | <h4>Background</h4>Local ablation has been proposed for treatment of liver tumours. Cryoshock, a variant of the systemic inflammatory response syndrome (SIRS), is a potentially fatal complication of cryoablation caused by systemic release of necrotic breakdown products from ablated liver. The proinflammatory cytokines tissue necrosis factor (TNF) alpha and interleukin (IL) 1 are important mediators of this response. This study assessed the risk of SIRS complicating electrolytic liver ablation by measuring circulating levels of inflammatory cytokines, other inflammatory markers and clinical markers of organ function.<h4>Methods</h4>Electrolytic liver ablation was performed in 16 pigs and four pigs served as controls. Platelet count, and serum levels of urea, creatinine, liver enzymes, C-reactive protein (CRP), TNF-alpha and IL-1beta were measured before treatment and for 72 h after the procedure.<h4>Results</h4>There were significant dose-related increases in CRP and alanine aminotransferase levels with liver electrolysis. There was no significant derangement in renal function or platelet count following ablation. A rise in serum TNF-alpha and IL-1beta levels was not associated with liver electrolysis.<h4>Conclusion</h4>There was no evidence of organ failure or significantly raised levels of proinflammatory cytokines as a result of liver electrolysis, suggesting that this is a safe procedure for liver ablation. |
Keywords: | Liver Serum Animals Swine Liver Neoplasms Alkaline Phosphatase Alanine Transaminase Tumor Necrosis Factor-alpha C-Reactive Protein Interleukin-1 Catheter Ablation Platelet Count Risk Factors Electrolysis Female Systemic Inflammatory Response Syndrome |
Description: | Copyright © 2004 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
DOI: | 10.1002/bjs.4400 |
Published version: | http://dx.doi.org/10.1002/bjs.4400 |
Appears in Collections: | Aurora harvest 2 Surgery publications |
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