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https://hdl.handle.net/2440/103714
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Type: | Journal article |
Title: | Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes |
Author: | Wu, T. Xie, C. Wu, H. Jones, K. Horowitz, M. Rayner, C. |
Citation: | Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 2017; 19(2):290-293 |
Publisher: | Wiley |
Issue Date: | 2017 |
ISSN: | 1462-8902 1463-1326 |
Statement of Responsibility: | Tongzhi Wu MD, Cong Xie, Hang, Karen L. Jones, Michael Horowitz, Christopher K. Rayner |
Abstract: | In rodents, metformin slows intestinal glucose absorption, potentially increasing exposure of the distal gut to glucose to enhance postprandial glucagon-like peptide-1 (GLP-1) secretion. We evaluated the effects of metformin on serum 3-O-methylglucose (3-OMG; a marker of glucose absorption) and plasma total GLP-1 concentrations during a standardized intraduodenal infusion of glucose and 3-OMG in patients with type 2 diabetes. A total of 12 patients, treated with metformin 850 mg twice daily or placebo for 7 days each in a double-blind, randomized, crossover design (14 days’ washout between treatments), were evaluated on days 5 or 8 of each treatment (6 subjects each). On each study day, 30 minutes after ingesting 850 mg metformin or placebo, patients received an infusion of glucose (60 g + 5 g 3-OMG, dissolved in water to 240 mL) via an intraduodenal catheter over the course of 120 minutes. Compared with placebo, metformin was associated with lower serum 3-OMG (P < .001) and higher plasma total GLP-1 (P = .003) concentrations. The increment in plasma GLP-1 after metformin vs placebo was related to the reduction in serum 3-OMG concentrations (P = .019). Accordingly, metformin inhibits small intestinal glucose absorption, which may contribute to augmented GLP-1 secretion in type 2 diabetes. |
Keywords: | 3-O-methylglucose; glucagon-like pepetide-1; intestinal glucose absorption; metformin |
Rights: | © 2016 John Wiley & Sons Ltd |
DOI: | 10.1111/dom.12812 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/627011 |
Published version: | http://dx.doi.org/10.1111/dom.12812 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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