Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/104075
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dc.contributor.author | McPherson, N. | - |
dc.contributor.author | Lane, M. | - |
dc.contributor.author | Sandeman, L. | - |
dc.contributor.author | Owens, J. | - |
dc.contributor.author | Fullston, T. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Nutrients, 2017; 9(2):122-1-122-17 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2440/104075 | - |
dc.description | Published: 9 February 2017 | - |
dc.description.abstract | Paternal obesity programs metabolic syndrome in offspring. Low-impact exercise in obese males improves the metabolic health of female offspring, however whether this occurred in male offspring remained unknown. C57BL/6NHsd (Harlan) mice were fed a control diet (CD; 6% fat, n = 7) or a high-fat diet (HFD; 21% fat, n = 16) for 18 weeks. After 9 weeks, HFD-fed mice either remained sedentary (HH, n = 8) or undertook low-moderate exercise (HE, n = 8) for another 9 weeks. Male offspring were assessed for glucose/insulin tolerance, body composition, plasma lipids, pancreatic islet cell morphology and microRNA expression. Founder HH induced glucose intolerance, insulin insensitivity, and hyperlipidaemia in male offspring (p < 0.05). Metabolic health was fully restored in male offspring by founder exercise to control levels. Founder HH reduced pancreatic β-cell area and islet cell size in male offspring, and altered the expression of 13 pancreatic microRNAs (p < 0.05). Founder HE led to partial restoration of pancreatic islet cell morphology and the expression of two pancreatic microRNAs (let7d-5p, 194-5p) in male offspring. Founder HE reduced male offspring adiposity, increased muscle mass, reduced plasma free fatty acids (FFAs), and further altered pancreatic microRNAs (35 vs. HH; 32 vs. CD) (p < 0.05). Low-impact exercise in obese fathers prior to conception, without dietary change, may be a viable intervention strategy to reduce the illeffects of obesity-induced paternal programming in male offspring. | - |
dc.description.statementofresponsibility | Nicole O. McPherson, Michelle Lane, Lauren Sandeman, Julie A. Owens and Tod Fullston | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.source.uri | http://dx.doi.org/10.3390/nu9020122 | - |
dc.subject | Sperm; fertility; nutrition | - |
dc.title | An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and microRNA expression in male offspring | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.3390/nu9020122 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McPherson, N. [0000-0002-3492-9403] | - |
dc.identifier.orcid | Owens, J. [0000-0002-7498-1353] | - |
dc.identifier.orcid | Fullston, T. [0000-0003-1314-3038] | - |
Appears in Collections: | Aurora harvest 3 Obstetrics and Gynaecology publications |
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File | Description | Size | Format | |
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hdl_104075.pdf | Published version | 971.92 kB | Adobe PDF | View/Open |
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