Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/104400
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Type: | Journal article |
Title: | Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease |
Author: | Chen, T. Xie, N. Viglianti, L. Zhou, Y. Tan, H. Tang, B. Tang, Y. |
Citation: | Faraday Discussions, 2017; 196:351-362 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2017 |
ISSN: | 1359-6640 1364-5498 |
Statement of Responsibility: | Tong Chen, Lucia Viglianti, Yabin Zhou, Hui Tan, Ben Zhong Tang and Youhong Tang |
Abstract: | Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted. |
Keywords: | Humans Creatinine Fluorescent Dyes Urinalysis Molecular Structure Fluorescence Renal Insufficiency, Chronic Serum Albumin, Human |
Description: | First published on 05 Sep 2016 |
Rights: | Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
DOI: | 10.1039/c6fd00153j |
Published version: | http://dx.doi.org/10.1039/c6fd00153j |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 7 |
Files in This Item:
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hdl_104400.pdf | Published version | 714.2 kB | Adobe PDF | View/Open |
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