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https://hdl.handle.net/2440/10467
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dc.contributor.author | Morrison, C. | - |
dc.contributor.author | Court, F. | - |
dc.contributor.author | Wemyss-Holden, S. | - |
dc.contributor.author | Teague, B. | - |
dc.contributor.author | Burrell, A. | - |
dc.contributor.author | Texler, M. | - |
dc.contributor.author | Metcalfe, M. | - |
dc.contributor.author | Dennison, A. | - |
dc.contributor.author | Maddern, G. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Surgical Endoscopy: surgical and interventional techniques, 2004; 18(10):1435-1441 | - |
dc.identifier.issn | 0930-2794 | - |
dc.identifier.issn | 1432-2218 | - |
dc.identifier.uri | http://hdl.handle.net/2440/10467 | - |
dc.description | The original publication is available at www.springerlink.com | - |
dc.description.abstract | Background: Pancreatic cancer has a dismal prognosis. Few patients are suitable for surgical resection, leaving the majority requiring symptom palliation. Current palliative techniques such as surgical bypass and endoscopic retrograde cholangiopancreatography (ERCP) are imperfect. A novel palliative therapy combining the symptom control of surgical bypass with the minimally invasive nature of ERCP is required. Methods: Perductal electrolytic ablation of pancreatic tissue, in a porcine model, was performed. There were two survival groups of 2 weeks (n = 4) and 8 weeks (n = 4). Postoperatively, serum biochemistry, amylase and C-reactive protein (CRP) were assessed. Histological examination of the pancreas, lungs, and kidneys was performed to determine the presence of acute pancreatitis or systemic inflammatory response. Results: An immediate transient increase in both amylase and CRP was seen. Although pancreatic histology demonstrated localised necrosis at the electrolytic site at 2 weeks, there was no evidence of generalized pancreatitis or a systemic inflammatory response at either 2 or 8 weeks. Conclusions: This study suggests that, although there is localized pancreatic necrosis and transient hyperamylasemia, perductal pancreatic electrolytic ablation is safe, with neither generalized pancreatitis nor a systemic inflammatory response, in the medium and long term. Although performed in normal porcine pancreas, because of the absence of a large-animal model of pancreatic cancer, this study suggests that electrolytic pancreatic ablation is safe. This technique may have a role in the palliation of pancreatic cancer, especially if delivered via a minimally, invasive approach, and warrants further investigation. | - |
dc.description.statementofresponsibility | C.P. Morrison, F.G. Court, S.A. Wemyss-Holden, B. D. Teague, A. Burrell, M. Texler, M.S. Metcalfe, A.R. Dennison and G.J. Maddern | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.source.uri | http://dx.doi.org/10.1007/s00464-003-9270-y | - |
dc.subject | Pancreas | - |
dc.subject | Electrolysis | - |
dc.subject | Local ablation | - |
dc.subject | Palliation | - |
dc.subject | Experimental studies | - |
dc.title | Perductal electrolytic ablation of the porcine pancreas | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s00464-003-9270-y | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Maddern, G. [0000-0003-2064-181X] | - |
Appears in Collections: | Aurora harvest 2 Surgery publications |
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