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https://hdl.handle.net/2440/106145
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dc.contributor.author | Li, F. | - |
dc.contributor.author | Gorle, A. | - |
dc.contributor.author | Ranson, M. | - |
dc.contributor.author | Vine, K. | - |
dc.contributor.author | Kinobe, R. | - |
dc.contributor.author | Feterl, M. | - |
dc.contributor.author | Warner, J. | - |
dc.contributor.author | Keene, F. | - |
dc.contributor.author | Collins, J. | - |
dc.contributor.author | Day, A. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Organic and Biomolecular Chemistry, 2017; 15(19):4172-4179 | - |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.issn | 1477-0539 | - |
dc.identifier.uri | http://hdl.handle.net/2440/106145 | - |
dc.description.abstract | The relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few examples of pharmacokinetic (PK) studies for drug⊂Q[n]. Drug-free Q[n] PK studies are the next step in determining the pharmacological applicability in their drug delivery potential. The results for the first PK and bio-distribution of drug-free ¹⁴C-Q[7] are described for administration via intravenous (i.v.) and intraperitoneal (i.p.) dosing. A study of oral administration of drug-free ¹⁴C-Q[8] has also been undertaken to determine the time course for the gastrointestinal tract (GIT), absorption and subsequent bio-distribution. Q[10], a potential drug carrier for larger drugs, was evaluated for its effect on the PK profile of a dinuclear ruthenium complex (Rubb₁₂), a potential antimicrobial agent. The Rubb₁₂⊂Q[10] complex and free Rubb₁₂ were administered by i.v. to determine differences in Rubb₁₂ plasma concentrations and organ accumulation. Interestingly, the PK profiles and bio-distribution observed for Q[7] showed similarities to those of Rubb₁₂⊂Q[10]. Drug-free Q[7] has a relatively fast plasma clearance and a generally low organ accumulation except for the kidneys. Drug-free Q[8] showed a low absorption from the GIT into the blood stream but the small percentage absorbed reflected the organ accumulation of Q[7]. These results provide a better understanding of the probable PK profile and bio-distribution for a drug⊂Q[n] through the influence of the drug delivery vehicle and the positive clearance of drug-free Q[n] via the kidneys supports its potential value in future drug delivery applications. | - |
dc.description.statementofresponsibility | Fangfei Li, Anil K. Gorle, Marie Ranson, Kara L. Vine, Robert Kinobe, Marshall Feterl, Jeffrey M. Warner, F. Richard Keene, J. Grant Collins and Anthony I. Day | - |
dc.language.iso | en | - |
dc.publisher | Royal Society of Chemistry | - |
dc.rights | This journal is © The Royal Society of Chemistry 2017 | - |
dc.source.uri | http://dx.doi.org/10.1039/c7ob00724h | - |
dc.subject | Animals | - |
dc.subject | Mice | - |
dc.subject | Ruthenium | - |
dc.subject | Organometallic Compounds | - |
dc.subject | Imidazoles | - |
dc.subject | Capsules | - |
dc.subject | Anti-Infective Agents | - |
dc.subject | Tissue Distribution | - |
dc.subject | Bridged-Ring Compounds | - |
dc.title | Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1039/c7ob00724h | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/514644 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Keene, F. [0000-0001-7759-0465] | - |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
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