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https://hdl.handle.net/2440/106352
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dc.contributor.author | Williams, B. | - |
dc.contributor.author | Tsangari, E. | - |
dc.contributor.author | Stansborough, R. | - |
dc.contributor.author | Marino, V. | - |
dc.contributor.author | Cantley, M. | - |
dc.contributor.author | Dharmapatni, A. | - |
dc.contributor.author | Gibson, R. | - |
dc.contributor.author | Perilli, E. | - |
dc.contributor.author | Crotti, T. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Inflammopharmacology: experimental and clinical studies, 2017; 25(1):55-68 | - |
dc.identifier.issn | 0925-4692 | - |
dc.identifier.issn | 1568-5608 | - |
dc.identifier.uri | http://hdl.handle.net/2440/106352 | - |
dc.description.abstract | Objective: To investigate the effect of caffeic acid phenethyl ester (CAPE) on local and systemic inflammation and bone loss in collagen antibody-induced arthritis (CAIA) mice. Methods: Four groups of mice (n = 8 per group) were allocated; control, CAPE (1 mg/kg), CAIA and CAIA + CAPE (1 mg/kg). Local inflammation and bone loss were evaluated using clinical paw scores, in vivo micro-computed tomography (micro-CT), histological assessment and tartrate-resistant acid phosphatase (TRAP) staining. Serum levels of C-reactive protein (CRP) and C-terminal telopeptide (CTX-1) were measured by ELISA. Jejunum and colon sections were evaluated histopathologically for damage and toxicity. Results: Greater paw scores and percentage change in paw volume were observed in CAIA + CAPE compared to the control groups (p < 0.05). Bone volume over time remained unchanged (p = 0.94) and the number of multinucleated TRAP-positive cells was greatest in CAIA + CAPE mice (p < 0.05). CRP and CTX-1 levels did not differ between groups. CAIA + CAPE mice exhibited lower colon toxicity scores and a reduced percentage of cavitated goblet cells in the colon crypts compared with CAIA mice (p = 0.026 and p = 0.003, respectively). Histopathology in the jejunum was not altered. Conclusion: CAPE did not reduce paw inflammation or bone loss in CAIA mice. CAPE reduced histopathological changes in the colon of CAIA mice. | - |
dc.description.statementofresponsibility | Bonnie Williams, Eleni Tsangari, Romany Stansborough, Victor Marino, Melissa Cantley, Anak Dharmapatni, Rachel Gibson, Egon Perilli, Tania Crotti | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.rights | © Springer International Publishing 2017 | - |
dc.source.uri | http://dx.doi.org/10.1007/s10787-016-0306-z | - |
dc.subject | CAIA; CAPE; gastrointestinal tract, bone; Micro-CT; inflammatory arthritis | - |
dc.title | Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s10787-016-0306-z | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Williams, B. [0000-0002-2356-105X] | - |
dc.identifier.orcid | Tsangari, E. [0000-0001-5675-1098] | - |
dc.identifier.orcid | Cantley, M. [0000-0002-7188-0928] | - |
dc.identifier.orcid | Gibson, R. [0000-0002-4796-1621] | - |
dc.identifier.orcid | Crotti, T. [0000-0002-5422-3758] | - |
Appears in Collections: | Aurora harvest 8 Pharmacology publications |
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