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https://hdl.handle.net/2440/107111
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Type: | Journal article |
Title: | Association of maternal diabetes/glycosuria and pre-pregnancy body mass index with offspring indicators of non-alcoholic fatty liver disease |
Author: | Patel, S. Lawlor, D. Callaway, M. Macdonald-Wallis, C. Sattar, N. Fraser, A. |
Citation: | BMC Pediatrics, 2016; 16(1):47-1-47-13 |
Publisher: | BioMed Central |
Issue Date: | 2016 |
ISSN: | 1471-2431 1471-2431 |
Statement of Responsibility: | Sumaiya Patel, Debbie A. Lawlor, Mark Callaway, Corrie Macdonald-Wallis, Naveed Sattar and Abigail Fraser |
Abstract: | Background: Little is known about early life determinants of non-alcoholic fatty liver disease (NAFLD). We examined associations of maternal pregnancy diabetes/glycosuria and pre-pregnancy body mass index (BMI) with offspring markers of NAFLD and liver pathology and examined mediation by birthweight and concurrent offspring adiposity. Methods: We used data from a UK prospective pregnancy cohort. Offspring underwent abdominal ultrasonography (USS) at mean age 17.8 years. Outcomes included USS-assessed fatty liver, estimated liver volume and shear velocity, a variant of elastography (a marker of liver fibrosis) (N = 1 215) and blood-based markers of liver pathology [alanine amino transferase, aspartate amino transferase, gamma- glutamyltransferase and haptoglobin] (N = 2 359). Results: 2.1 % (N = 25) of participants had USS-assessed fatty liver [maternal diabetes/glycosuria (N = 7) and no diabetes/glycosuria (N = 18)]. Maternal diabetes/glycosuria was associated with greater odds of offspring USS fatty liver in confounder adjusted models [adjusted odds ratio (aOR) 6.74 (95 % confidence interval (CI) 2.47, 18.40)] and higher shear velocity [adjusted ratio of geometric mean (aRGM):1.10 (95 % CI 1.05, 1.15)]. These associations were not mediated by offspring birthweight or concurrent adiposity. Maternal diabetes/glycosuria was not associated with liver volume or blood-based outcomes. Greater maternal pre-pregnancy BMI was associated with greater odds of offspring USS fatty liver [aOR 2.72 (95 % CI: 1.20, 6.15)], higher liver volume [aRGM 1.03 (95 % CI 1.00, 1.07)] and shear velocity [aRGM1.03 (95 % CI: 1.01, 1.06)] in confounder adjusted models. These associations were largely mediated by offspring adiposity. Maternal pre-pregnancy BMI was not consistently associated with blood-based outcomes. Conclusions: Results suggest that maternal pregnancy diabetes/glycosuria is associated with offspring NAFLD through mechanisms other than offspring’s own adiposity. |
Keywords: | Pregnancy diabetes; glycosuria; obesity; NAFLD; fetal overnutrition; ALSPAC |
Rights: | © Patel et al. 2016 |
DOI: | 10.1186/s12887-016-0585-y |
Published version: | http://dx.doi.org/10.1186/s12887-016-0585-y |
Appears in Collections: | Aurora harvest 8 Paediatrics publications |
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