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https://hdl.handle.net/2440/107112
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Type: | Journal article |
Title: | A novel recombinant canine adenovirus type 1 detected from acute lethal cases of infectious canine hepatitis |
Author: | Wong, M. Woolford, L. Hasan, N. Hemmatzadeh, F. |
Citation: | Viral Immunology, 2017; 30(4):258-263 |
Publisher: | Mary Ann Liebert |
Issue Date: | 2017 |
ISSN: | 0882-8245 1557-8976 |
Statement of Responsibility: | Magdelene Wong, Lucy Woolford, Noor Haliza Hasan and Farhid Hemmatzadeh |
Abstract: | In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centrilobular to panlobular necrohemorrhagic hepatitis and the development of disseminated intravascular coagulation in the terminal stages of disease. Comparison of partial genome sequences revealed that although these newly detected viruses mainly had CAdV-1 genome characteristics, their pVIII gene was more similar to that of CAdV-2. This likely suggests that a recombination has occurred between CAdV-1 and CAdV-2, which possibly explains the cause of vaccine failure or increased virulence of the virus in the observed ICH cases. |
Keywords: | acute infections canine adenovirus pathogenesis recombination vaccines veterinary |
Rights: | © Mary Ann Liebert, Inc. |
DOI: | 10.1089/vim.2016.0041 |
Published version: | http://dx.doi.org/10.1089/vim.2016.0041 |
Appears in Collections: | Aurora harvest 3 Paediatrics publications |
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