Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/112607
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DC Field | Value | Language |
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dc.contributor.author | Schlötterer, C. | - |
dc.contributor.author | Kofler, R. | - |
dc.contributor.author | Versace, E. | - |
dc.contributor.author | Tobler, R. | - |
dc.contributor.author | Franssen, S. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Heredity, 2015; 114(5):431-440 | - |
dc.identifier.issn | 0018-067X | - |
dc.identifier.issn | 1365-2540 | - |
dc.identifier.uri | http://hdl.handle.net/2440/112607 | - |
dc.description.abstract | Evolve and resequence (E&R) is a new approach to investigate the genomic responses to selection during experimental evolution. By using whole genome sequencing of pools of individuals (Pool-Seq), this method can identify selected variants in controlled and replicable experimental settings. Reviewing the current state of the field, we show that E&R can be powerful enough to identify causative genes and possibly even single-nucleotide polymorphisms. We also discuss how the experimental design and the complexity of the trait could result in a large number of false positive candidates. We suggest experimental and analytical strategies to maximize the power of E&R to uncover the genotype–phenotype link and serve as an important research tool for a broad range of evolutionary questions. | - |
dc.description.statementofresponsibility | C Schlötterer, R Kofler, E Versace, R Tobler and SU Franssen | - |
dc.language.iso | en | - |
dc.publisher | Springer Nature | - |
dc.rights | © 2015 Macmillan Publishers Limited All rights reserved This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | - |
dc.source.uri | http://dx.doi.org/10.1038/hdy.2014.86 | - |
dc.subject | Animals | - |
dc.subject | Drosophila melanogaster | - |
dc.subject | Adaptation, Physiological | - |
dc.subject | Gene Frequency | - |
dc.subject | Genotype | - |
dc.subject | Phenotype | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.subject | Research Design | - |
dc.subject | Genetic Variation | - |
dc.subject | Genetic Association Studies | - |
dc.subject | Biological Evolution | - |
dc.subject | High-Throughput Nucleotide Sequencing | - |
dc.title | Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/hdy.2014.86 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Tobler, R. [0000-0002-4603-1473] | - |
Appears in Collections: | Aurora harvest 3 Genetics publications |
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hdl_112607.pdf | Published Version | 683.13 kB | Adobe PDF | View/Open |
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