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https://hdl.handle.net/2440/112996
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Type: | Journal article |
Title: | Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with ADHD in a randomized controlled three-way crossover trial |
Author: | Milte, C. Parletta, N. Buckley, J. Coates, A. Young, R. Howe, P. |
Citation: | Journal of Attention Disorders, 2015; 19(11):954-964 |
Publisher: | SAGE Publications |
Issue Date: | 2015 |
ISSN: | 1087-0547 1557-1246 |
Statement of Responsibility: | Catherine M. Milte, Natalie Parletta, Jonathan D. Buckley, Alison M. Coates, Ross M. Young, and Peter R. C. Howe |
Abstract: | Objective: To investigate effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on attention, literacy, and behavior in children with ADHD. Method: Ninety children were randomized to consume supplements high in EPA, DHA, or linoleic acid (control) for 4 months each in a crossover design. Erythrocyte fatty acids, attention, cognition, literacy, and Conners’ Parent Rating Scales (CPRS) were measured at 0, 4, 8, 12 months. Results: Fifty-three children completed the treatment. Outcome measures showed no significant differences between the three treatments. However, in children with blood samples (n = 76-46), increased erythrocyte EPA + DHA was associated with improved spelling (r = .365, p < .001) and attention (r = −.540, p < .001) and reduced oppositional behavior (r = −.301, p < .003), hyperactivity (r = −.310, p < .001), cognitive problems (r = −.326, p < .001), Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) hyperactivity (r = −.270, p = .002) and DSM-IV inattention (r = −.343, p < .001). Conclusion: Increasing erythrocyte DHA and EPA via dietary supplementation may improve behavior, attention, and literacy in children with ADHD. |
Keywords: | ADD/ADHD; behavior; cognition; fatty acid; nutrition |
Rights: | © The Author(s) 2013 |
DOI: | 10.1177/1087054713510562 |
Grant ID: | http://purl.org/au-research/grants/arc/LP0776922 |
Published version: | http://dx.doi.org/10.1177/1087054713510562 |
Appears in Collections: | Aurora harvest 3 Molecular and Biomedical Science publications |
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