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https://hdl.handle.net/2440/113252
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dc.contributor.author | Simpson, B. | - |
dc.contributor.author | Luo, X. | - |
dc.contributor.author | Costabile, M. | - |
dc.contributor.author | Caughey, G. | - |
dc.contributor.author | Wang, J. | - |
dc.contributor.author | Claudie, D. | - |
dc.contributor.author | McKinnon, R. | - |
dc.contributor.author | Semple, S. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Natural Products, 2014; 77(1):85-91 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.issn | 1520-6025 | - |
dc.identifier.uri | http://hdl.handle.net/2440/113252 | - |
dc.description | Published: January 8, 2014 | - |
dc.description.abstract | Dodonaea polyandra is a medicinal plant used traditionally by the Kuuku I'yu (Northern Kaanju) indigenous people of Cape York Peninsula, Australia. The most potent of the diterpenoids previously identified from this plant, polyandric acid A (1), has been examined for inhibition of pro-inflammatory cytokine production and other inflammatory mediators using well-established acute and chronic mouse ear edema models and in vitro cellular models. Topical application of 1 significantly inhibited interleukin-1β production in mouse ear tissue in an acute model. In a chronic skin inflammation model, a marked reduction in ear thickness, associated with significant reduction in myeloperoxidase accumulation, was observed. Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ionomycin showed a significant reduction in IL-6 secretion. The present study provides evidence that the anti-inflammatory properties of 1 are due to inhibition of pro-inflammatory cytokines associated with skin inflammation and may be useful in applications for skin inflammatory conditions including psoriasis and dermatitis. | - |
dc.description.statementofresponsibility | Bradley S. Simpson, Xianling Luo, Maurizio Costabile, Gillian E. Caughey, Jiping Wang, David J. Claudie, Ross A. McKinnon, and Susan J. Semple | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.rights | © 2014 American Chemical Society and American Society of Pharmacognosy | - |
dc.source.uri | http://dx.doi.org/10.1021/np400704b | - |
dc.subject | Macrophages | - |
dc.title | Polyandric acid A, a clerodane diterpenoid from the Australian medicinal plant Dodonaea polyandra, attenuates pro-inflammatory cytokine secretion in vitro and in vivo | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1021/np400704b | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1017556 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Caughey, G. [0000-0003-1192-4121] | - |
Appears in Collections: | Aurora harvest 3 Pharmacology publications |
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