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https://hdl.handle.net/2440/11340
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Type: | Journal article |
Title: | The maculatin peptides from the skin glands of the tree frog litoria genimaculata: a comparison of the structures and antibacterial activities of Maculatin 1.1 and Caerin 1.1 |
Author: | Rozek, T. Waugh, R. Steinborner, S. Bowie, J. Tyler, M. Wallace, J. |
Citation: | Journal of Peptide Science, 1998; 4(2):111-115 |
Publisher: | JOHN WILEY & SONS LTD |
Issue Date: | 1998 |
ISSN: | 1075-2617 1099-1387 |
Statement of Responsibility: | Tomas Rozek, Russell J. Waugh, Simon T. Steinborner, John H. Bowie, Michael J. Tyler, John C. Wallace |
Abstract: | Six peptides have been isolated and characterized from the dorsal glands of the tree frog Litoria genimaculata. One of these is the known hypotensive peptide caerulein; the others have been named maculatins. The amino acid sequences of the maculatin peptides have been determined using a combination of fast atom bombardment mass spectrometry and automated Edman sequencing. Four of the maculatin peptides show antibiotic activity, with maculatin 1.1 [GLFGVLAKVAAHVVPAIAEHF(NH2)] showing the most pronounced activity, particularly against gram-positive organisms. Maculatin 1.1 resembles the known caerin 1 antibiotic peptides, except that four of the central amino acid residues (of the caerin 1 system) are missing in maculatin 1.1. A comparison of the antibiotic activity of maculatin 1.1 with those of caerin 1.1 is reported. |
Keywords: | Litoria genimaculata skin glands glandular secretions peptides antibiotic activity maculatins 1 caerin 1.1 |
Rights: | © 1998 European Peptide Society and John Wiley & Sons, Ltd. |
DOI: | 10.1002/(SICI)1099-1387(199804)4:2<111::AID-PSC134>3.0.CO;2-8 |
Published version: | http://dx.doi.org/10.1002/(sici)1099-1387(199804)4:2%3C111::aid-psc134%3E3.0.co;2-8 |
Appears in Collections: | Aurora harvest 7 Biochemistry publications |
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