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https://hdl.handle.net/2440/11389
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dc.contributor.author | Cavanaugh, J. | - |
dc.contributor.author | Callen, D. | - |
dc.contributor.author | Wilson, S. | - |
dc.contributor.author | Stanford, P. | - |
dc.contributor.author | Sraml, M. | - |
dc.contributor.author | Gorska, M. | - |
dc.contributor.author | Crawford, J. | - |
dc.contributor.author | Whitmore, S. | - |
dc.contributor.author | Shlegel, C. | - |
dc.contributor.author | Foote, S. | - |
dc.contributor.author | Kohonen-Corish, M. | - |
dc.contributor.author | Pavli, P. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Annals of Human Genetics, 1998; 62(4):291-298 | - |
dc.identifier.issn | 0003-4800 | - |
dc.identifier.issn | 1469-1809 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11389 | - |
dc.description.abstract | A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | © 1998 University College London | - |
dc.source.uri | http://dx.doi.org/10.1046/j.1469-1809.1998.6240291.x | - |
dc.subject | Chromosomes, Human, Pair 16 | - |
dc.subject | Humans | - |
dc.subject | Inflammatory Bowel Diseases | - |
dc.subject | Crohn Disease | - |
dc.subject | Genetic Predisposition to Disease | - |
dc.subject | Chromosome Mapping | - |
dc.subject | Pedigree | - |
dc.subject | Genotype | - |
dc.subject | Haplotypes | - |
dc.subject | Lod Score | - |
dc.subject | Australia | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Genetic Linkage | - |
dc.title | Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1046/j.1469-1809.1998.6240291.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Callen, D. [0000-0002-6189-9991] | - |
Appears in Collections: | Aurora harvest 2 Genetics publications |
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