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https://hdl.handle.net/2440/114699
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Type: | Journal article |
Title: | Fetal gender of the first born and the recurrent risk of spontaneous preterm birth |
Author: | Kamphuis, E. Koullali, B. Hof, M. De Groot, C. Kazemier, B. Robertson, S. Mol, B. Ravelli, A. |
Citation: | American Journal of Perinatology: neonatal and maternal-fetal medicine, 2015; 32(14):1305-1310 |
Publisher: | Thieme Medical Publishers |
Issue Date: | 2015 |
ISSN: | 0735-1631 1098-8785 |
Statement of Responsibility: | Esmé I. Kamphuis, Bouchra Koullali, Michel Hof, Christianne J. M. de Groot, Brenda M. Kazemier, Sarah Robertson, Ben W. J. Mol, Anita C. Ravelli |
Abstract: | Objective: To study, in women with a spontaneous preterm birth (sPTB) in the first pregnancy, the effect of fetal sex in that first pregnancy on the recurrent sPTB risk. Study Design: A nationwide retrospective cohort study (data from National Perinatal Registry) on all women with two sequential singleton pregnancies (1999–2009) with the first delivery ending in sPTB <37 weeks. We used logistic regression analysis to study the association between fetal gender in the first pregnancy and the risk of recurrent sPTB. We repeated the analysis for sPTB < 32 weeks. Results: The overall incidence of sPTB <37 weeks in the first pregnancy was 4.5% (15,351/343,853). Among those 15,351 women, the risk of recurrent sPTB <37 weeks was increased when the first fetus was female compared when that fetus was male (15.8 vs. 15.2%; adjusted odds ratio [aOR] 1.2; 95% confidence interval [CI] 1.05–1.3). A similar effect was seen for sPTB <32weeks (8.2 vs. 5.9%; aOR 4.5; 95% CI 1.5–13). Conclusion: Women who suffer sPTB of a female fetus have an increased risk of recurrent sPTB compared with women who suffer sPTB of a male fetus. This information provides proof for the hypothesis that sPTB is due to an independent maternal and fetal factor. |
Keywords: | Fetal gender - recurrent spontaneous preterm birth |
Rights: | © 2015 by Thieme Medical Publishers |
DOI: | 10.1055/s-0035-1563716 |
Published version: | http://dx.doi.org/10.1055/s-0035-1563716 |
Appears in Collections: | Aurora harvest 3 Paediatrics publications |
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