Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/114705
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults |
Author: | Lock, M.C. Tellam, R.L. Botting, K.J. Wang, K.C.W. Selvanayagam, J.B. Brooks, D.A. Seed, M. Morrison, J.L. |
Citation: | The Journal of Physiology, 2018; 596(23):5625-5640 |
Publisher: | Wiley |
Issue Date: | 2018 |
ISSN: | 0022-3751 1469-7793 |
Statement of Responsibility: | Mitchell C. Lock, Ross L. Tellam, Kimberley J. Botting, Kimberley C.W.Wang, Joseph B. Selvanayagam, Doug A. Brooks, Mike Seed and Janna L. Morrison |
Abstract: | Myocardial infarction is a primary contributor towards the global burden of cardiovascular disease. Rather than repairing the existing damage of myocardial infarction, current treatments only address the symptoms of the disease and reducing the risk of a secondary infarction. Cardiac regenerative capacity is dependent on cardiomyocyte proliferation, which concludes soon after birth in humans and precocial species such as sheep. Human fetal cardiac tissue has some ability to repair following tissue damage, whereas a fully matured human heart has minimal capacity for cellular regeneration. This is in contrast to neonatal mice and adult zebrafish hearts, which retain the ability to undergo cardiomyocyte proliferation and can regenerate cardiac tissue after birth. In mice and zebrafish models, microRNAs (miRNAs) have been implicated in the regulation of genes involved in cardiac cell cycle progression and regeneration. However, the significance of miRNA regulation in cardiomyocyte proliferation for humans and other large mammals, where the timing of heart development in relation to birth is similar, remains unclear. miRNAs may be valuable targets for therapies that promote cardiac repair after injury. Therefore, elucidating the role of specific miRNAs in large animals, where heart development closely resembles that of humans, remains vitally important for identifying therapeutic targets that may be translated into clinical practice focussed on tissue repair. |
Keywords: | Heart Myocytes, Cardiac Fetus Animals Humans Heart Diseases MicroRNAs Risk Regeneration Cell Proliferation |
Rights: | © 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society |
DOI: | 10.1113/jp276072 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1066916 http://purl.org/au-research/grants/arc/FT170100431 http://purl.org/au-research/grants/nhmrc/1090888 |
Published version: | http://dx.doi.org/10.1113/jp276072 |
Appears in Collections: | Aurora harvest 8 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.