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https://hdl.handle.net/2440/11524
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Type: | Journal article |
Title: | AZT blocks down-regulation of IL-2 and IFN-γ gene expression in HIV acutely infected cells |
Other Titles: | AZT blocks down-regulation of IL-2 and IFN-gamma gene expression in HIV acutely infected cells |
Author: | Fan, J. Li, P. Kok, T. Burrell, C. |
Citation: | Archives of Virology, 1997; 142(5):1035-1043 |
Publisher: | SPRINGER-VERLAG WIEN |
Issue Date: | 1997 |
ISSN: | 0304-8608 1432-8798 |
Statement of Responsibility: | J. Fan, P. Li, T.-W. Kok, C. J. Burrell |
Abstract: | HIV infection causes dysregulation of cytokine gene expression in CD4⁺ T cells of the infected host. Azidothymidine (AZT) inhibits HIV repli-cation by blocking reverse transcription. Using a one-stop cell-to-cell HIV infection model, we have investigated the expression of several key cytokines in HIV infected T cells in the absence or presence of AZT treatment. Acute HIV infection of T cells resulted in dramatic down regulation of the expression of IL-2 and INFg mRNA. While β-actin mRNA levels remained constant in both AZT-free and AZT treated cultures after HIV infection, it was found that AZT blocked the down regulation of IL-2 mRNA and INFg mRNA in CD4⁺ T cells acutely infected with HIV. |
Keywords: | CD4-Positive T-Lymphocytes Humans HIV Infections RNA, Messenger Zidovudine Interleukin-2 Down-Regulation Interferon-gamma |
DOI: | 10.1007/s007050050139 |
Published version: | http://dx.doi.org/10.1007/s007050050139 |
Appears in Collections: | Aurora harvest 2 Microbiology and Immunology publications |
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