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https://hdl.handle.net/2440/11561
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dc.contributor.author | Akoum, A. | - |
dc.contributor.author | Lemay, A. | - |
dc.contributor.author | McColl, S. | - |
dc.contributor.author | Turcot-Tremblay, L. | - |
dc.contributor.author | Maheux, R. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Fertility and Sterility, 1996; 66(1):17-23 | - |
dc.identifier.issn | 0015-0282 | - |
dc.identifier.issn | 1556-5653 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11561 | - |
dc.description.abstract | <h4>Objective</h4>To estimate the concentration and the biologic activity of monocyte chemotactic protein-1 (MCP-1) in the peritoneal fluid (PF) of women with and without endometriosis.<h4>Design</h4>A case control study was conducted.<h4>Setting</h4>Gynecology clinic and Laboratories of endocrinology of reproduction and immunology.<h4>Patients</h4>Women presenting for infertility, pelvic pain, or tubal ligation in which endometriosis was diagnosed at laparoscopy (n = 36) and normal fertile controls presenting for tubal ligation (n = 21).<h4>Interventions</h4>Collection of PF via laparoscopy.<h4>Main outcome measures</h4>Determination of PF concentrations of MCP-1 by an ELISA and evaluation of its monocyte chemotactic activity using a human hystiocytic cell line (U937). RESULTS. The concentration of MCP-1 (median, range of values) was increased in the PF of endometriosis patients (283, 0 to 1,930 pg/mL; conversion factor to SI unit, 0.155) compared with the control group (140, 0 to 435 pg/mL). The most significant elevation of MCP-1 levels was found in the stage II of the disease (371, 200 to 1,930 pg/mL). An increased chemotactic activity for monocytes (mean number of migrating cells/mm2 +/- SD) also was found in stages I (1,460 +/- 312) and II (1,541 +/- 336) of the disease when compared with fertile controls (393 +/- 56). Forty percent to 53% of this activity was inhibited in the presence of an antibody specific to MCP-1.<h4>Conclusions</h4>These observations are consistent with previous data indicating increased leukocyte chemotaxis in the PF of patients with endometriosis and suggest that MCP-1 may play a relevant role in the peritoneal inflammatory reaction associated with the disease. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.source.uri | http://dx.doi.org/10.1016/s0015-0282(16)58381-2 | - |
dc.subject | Monocytes | - |
dc.subject | Ascitic Fluid | - |
dc.subject | Humans | - |
dc.subject | Endometriosis | - |
dc.subject | Case-Control Studies | - |
dc.subject | Chemotaxis, Leukocyte | - |
dc.subject | Osmolar Concentration | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Chemokine CCL2 | - |
dc.title | Elevated concentration and biologic activity of monocyte chemotactic protein-1 levels in the peritoneal fluid of patients with endometriosis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/s0015-0282(16)58381-2 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McColl, S. [0000-0003-0949-4660] | - |
Appears in Collections: | Aurora harvest 2 Microbiology and Immunology publications |
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