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https://hdl.handle.net/2440/11580
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Dent, L. | - |
dc.contributor.author | Daly, C. | - |
dc.contributor.author | Mayrhofer, G. | - |
dc.contributor.author | Zimmerman, T. | - |
dc.contributor.author | Hallett, A. | - |
dc.contributor.author | Bignold, L. | - |
dc.contributor.author | Creaney, J. | - |
dc.contributor.author | Parsons, J. | - |
dc.contributor.editor | Mansfield, J.M. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Infection and Immunity, 1999; 67(2):989-993 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.issn | 1098-5522 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11580 | - |
dc.description.abstract | In this study, interleukin-5 (IL-5) transgenic mice with lifelong eosinophilia were assessed for resistance to primary infections with two tissue-invading nematodes, Nippostrongylus brasiliensisand Toxocara canis. Relative to nontransgenic littermates, three lines of IL-5 transgenic mice with varying degrees of eosinophilia all displayed enhanced resistance to N. brasiliensis. Although the timing of final worm expulsion was similar in transgenic and nontransgenic hosts, intestinal worms in transgenic mice were fewer in number throughout infection, failed to increase in size over the course of the infection, and were much less fecund. In contrast, T. canis larvae were recovered in similar numbers from tissues of transgenic mice with “low” or “high” eosinophilia and from nontransgenic mice. These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils. | - |
dc.description.statementofresponsibility | Lindsay A. Dent, Christine M. Daly, Graham Mayrhofer, Trudy Zimmerman, Ann Hallett, Leon P. Bignold, Jenette Creaney, and Jim C. Parsons | - |
dc.language.iso | en | - |
dc.publisher | American Society for Microbiology | - |
dc.rights | Copyright © 1999 American Society for Microbiology | - |
dc.source.uri | http://dx.doi.org/10.1128/iai.67.2.989-993.1999 | - |
dc.subject | Intestine, Small | - |
dc.subject | Ovum | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred CBA | - |
dc.subject | Mice, Transgenic | - |
dc.subject | Mice | - |
dc.subject | Toxocara canis | - |
dc.subject | Nippostrongylus | - |
dc.subject | Toxocariasis | - |
dc.subject | Strongylida Infections | - |
dc.subject | Eosinophilia | - |
dc.subject | Interleukin-5 | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Immunity, Innate | - |
dc.title | Interleukin-5 transgenic mice show enhanced resistance to primary infections with Nippostrongylus brasiliensis but not primary infections with Toxacara caris | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1128/iai.67.2.989-993.1999 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Dent, L. [0000-0002-3521-408X] | - |
Appears in Collections: | Aurora harvest 7 Microbiology and Immunology publications |
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