Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/116527
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype |
Author: | Direk, N. Williams, S. Smith, J. Ripke, S. Air, T. Amare, A. Amin, N. Baune, B. Bennett, D. Blackwood, D. Boomsma, D. Breen, G. Buttenschøn, H. Byrne, E. Børglum, A. Castelao, E. Cichon, S. Clarke, T. Cornelis, M. Dannlowski, U. et al. |
Citation: | Biological Psychiatry, 2017; 82(5):322-329 |
Publisher: | Society of Biological Psychiatry |
Issue Date: | 2017 |
ISSN: | 0006-3223 1873-2402 |
Statement of Responsibility: | Nese Direk, Stephanie Williams, Jennifer A. Smith ... Tracy M. Air … Azmeraw T. Amare … Bernhard T. Baune ... et al. |
Abstract: | Background: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder. Methods: We analyzed two prior studies of 70,017 participants of European ancestry from general and clinical populations in the discovery stage. We performed a replication meta-analysis of 28,328 participants. Single nucleotide polymorphism (SNP)-based heritability and genetic correlations were calculated using linkage disequilibrium score regression. Discovery and replication analyses were performed using a p-value-based meta-analysis. Lifetime major depressive disorder and depressive symptom scores were used as the outcome measures. Results: The SNP-based heritability of major depressive disorder was 0.21 (SE = 0.02), the SNP-based heritability of depressive symptoms was 0.04 (SE = 0.01), and their genetic correlation was 1.001 (SE = 0.2). We found one genome-wide significant locus related to the broad depression phenotype (rs9825823, chromosome 3: 61,082,153, p = 8.2 × 10–9) located in an intron of the FHIT gene. We replicated this SNP in independent samples (p = .02) and the overall meta-analysis of the discovery and replication cohorts (1.0 × 10–9). Conclusions: This large study identified a new locus for depression. Our results support a continuum between depressive symptoms and major depressive disorder. A phenotypically more inclusive approach may help to achieve the large sample sizes needed to detect susceptibility loci for depression. |
Keywords: | CHARGE consortium Depressive symptoms FHIT gene Genome-wide association study Major depressive disorder Psychiatric Genomics Consortium |
Rights: | © 2016 Society of Biological Psychiatry |
DOI: | 10.1016/j.biopsych.2016.11.013 |
Published version: | http://dx.doi.org/10.1016/j.biopsych.2016.11.013 |
Appears in Collections: | Aurora harvest 8 Psychology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.