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https://hdl.handle.net/2440/11703
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dc.contributor.author | Shoubridge, C. | - |
dc.contributor.author | Steeb, C. | - |
dc.contributor.author | Read, L. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | American Journal of Physiology: Gastrointestinal and Liver Physiology, 2001; 281(6):G1378-G1384 | - |
dc.identifier.issn | 0193-1857 | - |
dc.identifier.issn | 1522-1547 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11703 | - |
dc.description | Published 1 December 2001 | - |
dc.description.abstract | In contrast to the adult gut, the immature intestine is refractory to subcutaneously infused insulin-like growth factor I (IGF-I). IGF binding protein (IGFBP) mRNA expression was characterized in intestinal tissues from 6-, 19-, and 90-day-old rats to determine if changes in local expression could account for this age-related change in IGF-I potency. For all age groups, IGFBP-3 to -6, but not IGFBP-1 or -2, were detected by Northern blot analysis. IGFBP-3, -4, and -5 were more intensely expressed in the 6-day-old rat intestine compared with weanling or adult tissue. In contrast, IGFBP-6 expression peaked at the time of weaning. In situ hybridization showed IGFBP-3 to -6 expression was confined to cells of the lamina propria and submucosa and also in the muscularis layer for IGFBP-5. Furthermore, the pattern of IGFBP-5 localization in the intestine changed with development. The findings indicate that the expression of IGFBP-3 to -6 is higher in the immature intestine compared with the adult intestine, suggesting locally produced IGFBPs may inhibit systemically derived IGF-I action in the intestine. Therefore, changes to local IGFBP expression may contribute to the varying response of the rat intestine to IGF-I peptides during postnatal development. | - |
dc.description.statementofresponsibility | C. A. Shoubridge, C.-B. Steeb, and L. C. Read | - |
dc.language.iso | en | - |
dc.publisher | American Physiological Society | - |
dc.rights | Copyright © 2001 the American Physiological Society | - |
dc.source.uri | http://ajpgi.physiology.org/content/281/6/G1378 | - |
dc.subject | insulin-like growth factor I; Northern blot; growth; in situ hybridization; gastrointestinal tract | - |
dc.title | IGFBP mRNA expression in small intestine of rat during postnatal development | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpgi.2001.281.6.g1378 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Shoubridge, C. [0000-0002-0157-3084] | - |
Appears in Collections: | Aurora harvest 2 Physiology publications |
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