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https://hdl.handle.net/2440/11706
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DC Field | Value | Language |
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dc.contributor.author | Marsh, A. | - |
dc.contributor.author | Gibson, K. | - |
dc.contributor.author | Wu, J. | - |
dc.contributor.author | Owens, P. | - |
dc.contributor.author | Owens, J. | - |
dc.contributor.author | Lumbers, E. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2001; 281(1):R318-R326 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11706 | - |
dc.description.abstract | In the adult, insulin-like growth factor I (IGF-I) increases glomerular filtration rate (GFR) and renal blood flow (RBF) during both acute and chronic treatment. To study its effects on the developing kidney, chronically catheterized fetal sheep (120 ± 1 days gestation) were infused intravenously for up to 10 days with 80 µg/h IGF-I (n = 5) or vehicle (0.1% BSA in saline, n = 6). In contrast to previous acute studies in adult rats and humans, after 4 h of IGF-I fetal GFR and RBF were unchanged. Fractional sodium reabsorption increased (P < 0.05). However, by 4 days, GFR per kilogram had risen by 35 ± 13% (P < 0.05), whereas RBF remained unchanged. Tubular growth and maturation may have occurred, as proximal tubular sodium reabsorption increased by ~35% (P < 0.005). Therefore, despite a marked increase in filtered sodium (~30%, P < 0.05), fractional sodium reabsorption did not change. Although the effects of IGF-I on renal function were delayed, plasma renin activity and concentration were both elevated after 4 h and remained high at 4 days (P < 0.05). Despite this, arterial pressure and heart rate did not change. Kidneys of IGF-I-infused fetuses weighed ~30% more (P = 0.05) and contained ~75% more renin than control fetuses (P < 0.005). Thus, in the fetus, the renal effects of long-term IGF-I infusion are very different from the adult, possibly because IGF-I stimulated kidney growth. | - |
dc.description.statementofresponsibility | Amanda C. Marsh, Karen J. Gibson, June Wu, Phillip C. Owens, Julie A. Owens and Eugenie R. Lumbers | - |
dc.language.iso | en | - |
dc.publisher | American Physiological Society | - |
dc.rights | Copyright © 2001 by the American Physiological Society | - |
dc.source.uri | http://ajpregu.physiology.org/content/281/1/R318 | - |
dc.subject | Kidney | - |
dc.subject | development | - |
dc.subject | renin-angiotensin system | - |
dc.subject | glomerular filtration | - |
dc.title | Chronic effect of insulin-like growth factor I on renin synthesis, secretion, and renal function in fetal sheep | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.2001.281.1.r318 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Owens, J. [0000-0002-7498-1353] | - |
Appears in Collections: | Aurora harvest 2 Physiology publications |
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