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https://hdl.handle.net/2440/118279
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Type: | Journal article |
Title: | Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially |
Author: | Hughes, A.M. Lucas, R.M. Mcmichael, A.J. Dwyer, T. Pender, M.P. van der Mei, I. Taylor, B.V. Valery, P. Chapman, C. Coulthard, A. Dear, K. Kilpatrick, T.J. Williams, D. Ponsonby, A.L. |
Citation: | Clinical and Experimental Immunology, 2013; 172(3):466-474 |
Publisher: | Wiley |
Issue Date: | 2013 |
ISSN: | 0009-9104 1365-2249 |
Statement of Responsibility: | A.-M. Hughes, R.M. Lucas, A.J. McMichael, T. Dwyer, M.P. Pender, I. van der Mei, B.V. Taylor, P. Valery, C. Chapman, A. Coulthard, K. Dear, T.J. Kilpatrick, D. Williams, and A.-L. Ponsonby |
Abstract: | The increasing prevalence of immune-related diseases, including multiple sclerosis, may be partly explained by reduced microbial burden during childhood. Within a multi-centre case-control study population, we examined: (i) the co-morbid immune diseases profile of adults with a first clinical diagnosis of central nervous system demyelination (FCD) and (ii) sibship structure in relation to an autoimmune (FCD) and an allergic (asthma) disease. FCD cases (n = 282) were aged 18-59 years; controls (n = 558) were matched on age, sex and region. Measures include: history of doctor-diagnosed asthma; sibling profile (number; dates of birth); and regular childcare attendance. FCD cases did not differ from controls with regard to personal or family history of allergy, but had a greater likelihood of chronic fatigue syndrome [odds ratio (OR) = 3·11; 95% confidence interval (CI) 1·11, 8·71]. Having any younger siblings showed reduced odds of FCD (OR = 0·68; 95% CI: 0·49, 0·95) but not asthma (OR = 1·47; 95% CI: 0·91, 2·38). In contrast, an increasing number of older siblings was associated with reduced risk of asthma (P trend = 0·04) but not FCD (P trend = 0·66). Allergies were not over-represented among people presenting with FCD. Sibship characteristics influence both FCD and asthma risk but the underlying mechanisms differ, possibly due to the timing of the putative 'sibling effect'. |
Keywords: | Allergy; asthma; autoimmunity; hygiene; multiple sclerosis; siblings |
Rights: | © 2013 British Society for Immunology |
DOI: | 10.1111/cei.12077 |
Grant ID: | NHMRC NHMRC |
Published version: | http://dx.doi.org/10.1111/cei.12077 |
Appears in Collections: | Aurora harvest 3 Public Health publications |
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