Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/118572
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Vitamin D status: multifactorial contribution of environment, genes and other factors in healthy Australian adults across a latitude gradient |
Author: | Lucas, R.M. Ponsonby, A.L. Dear, K. Valery, P.C. Taylor, B. Van Der Mei, I. McMichael, A.J. Pender, M.P. Chapman, C. Coulthard, A. Kilpatrick, T.J. Stankovich, J. Williams, D. Dwyer, T. |
Citation: | The Journal of Steroid Biochemistry and Molecular Biology, 2013; 136(1):300-308 |
Publisher: | Elsevier |
Issue Date: | 2013 |
ISSN: | 0960-0760 1879-1220 |
Statement of Responsibility: | Robyn M. Lucas, Anne-Louise Ponsonby, Keith Dear, Patricia C. Valery, Bruce Taylor, Ingrid van der Mei, Anthony J. McMichael, Michael P. Pender, Caron Chapman, Alan Coulthard, Trevor J. Kilpatrick, Jim Stankovich, David Williams, Terence Dwyer |
Abstract: | Vitamin D deficiency is common and implicated in risk of several human diseases. Evidence on the relative quantitative contribution of environmental, genetic and phenotypic factors to vitamin D status (assessed by the serum concentration of 25-hydroxyvitamin D, 25(OH)D) in free-living populations is sparse. We conducted a cross-sectional study of 494 Caucasian adults aged 18–61 years, randomly selected from the Australian Electoral Roll according to groups defined by age, sex and region (spanning 27°–43° South). Data collected included personal characteristics, sun exposure behaviour, biomarkers of skin type and past sun exposure, serum 25(OH)D concentration and candidate single nucleotide polymorphisms. Ambient ultraviolet radiation (UVR) levels in the month six weeks before blood sampling best predicted vitamin D status. Serum 25(OH)D concentration increased by 10 nmol/L as reported time in the sun doubled. Overall, 54% of the variation in serum 25(OH)D concentration could be accounted for: 36% of the variation was explained by sun exposure-related factors; 14% by genetic factors (including epistasis) and 3.5% by direct measures of skin phenotype. Novel findings from this study are demonstration of gene epistasis, and quantification of the relative contribution of a wide range of environmental, constitutional and genetic factors to vitamin D status. Ambient UVR levels and time in the sun were of prime importance but it is nonetheless important to include the contribution of genetic factors when considering sun exposure effects. |
Keywords: | Vitamin D; 25-hydroxyvitamin D; sun exposure; genetics; diet |
Rights: | © 2013 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.jsbmb.2013.01.011 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/316901 http://purl.org/au-research/grants/nhmrc/224215 |
Published version: | http://dx.doi.org/10.1016/j.jsbmb.2013.01.011 |
Appears in Collections: | Aurora harvest 4 Public Health publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.