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https://hdl.handle.net/2440/11883
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Type: | Journal article |
Title: | Ontogenic and nutritional changes in circulating insulin-like growth factor (IGF)-I, IGF-II, and IGF-binding proteins in growing ewe and ram lambs |
Author: | Gatford, K. Quinn, K. Walton, P. Grant, P. Hosking, B. Egan, A. Owens, P. |
Citation: | Journal of Endocrinology, 1997; 155(1):47-54 |
Publisher: | Society for Endocrinology |
Issue Date: | 1997 |
ISSN: | 0022-0795 1479-6805 |
Statement of Responsibility: | KL Gatford, KJ Quinn, PE Walton, PA Grant, BJ Hosking, AR Egan, and PC Owens |
Abstract: | The ontogeny of the IGF endocrine system was investigated in 15 young lambs before and after weaning at 62 days of age. Before weaning, plasma IGF-I concentrations were higher in rams than ewes, and plasma concentrations of IGF-II and IGF-binding protein-3 (IGFBP-3) also tended to be higher in rams than in ewes. Feed intake of ewes and rams was restricted after weaning to remove sex differences in feed intake. Plasma concentrations of IGF-I and IGFBP-3 did not differ between rams and ewes at 100 days of age, but plasma IGF-II was higher in rams than in ewes at this time. Since circulating concentrations of GH were higher in rams than in ewes at 100 days of age, this implies that the restricted feed intake blocked the IGF-I and IGFBP-3 responses to GH. We conclude that sex differences in circulating IGF-I and IGFBP-3 concentrations in the growing lamb alter with age, and are not present when nutrition is restricted. |
Keywords: | Animals Sheep Growth Hormone Somatomedins Insulin-Like Growth Factor I Insulin-Like Growth Factor II Insulin-Like Growth Factor Binding Protein 3 Sex Factors Weaning Aging Female Male Animal Nutritional Physiological Phenomena |
Rights: | Copyright © 1997 by Society for Endocrinology |
DOI: | 10.1677/joe.0.1550047 |
Published version: | http://joe.endocrinology-journals.org/cgi/content/abstract/155/1/47 |
Appears in Collections: | Aurora harvest 7 Physiology publications |
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