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https://hdl.handle.net/2440/119202
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Type: | Journal article |
Title: | Axon density and axon orientation dispersion in children born preterm |
Author: | Kelly, C.E. Thompson, D.K. Chen, J. Leemans, A. Adamson, C.L. Inder, T.E. Cheong, J.L.Y. Doyle, L.W. Anderson, P.J. |
Citation: | Human Brain Mapping, 2016; 37(9):3080-3102 |
Publisher: | Wiley |
Issue Date: | 2016 |
ISSN: | 1065-9471 1097-0193 |
Statement of Responsibility: | Claire E. Kelly, Deanne K. Thompson, Jian Chen, Alexander Leemans, Christopher L. Adamson, Terrie E. Inder, Jeanie L.Y. Cheong, Lex W. Doyle Peter J. Anderson |
Abstract: | Background: Very preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes. Methods: FA, neurite dispersion, and neurite density were estimated from multishell diffusion magnetic resonance images for 145 VPT and 33 control 7‐year‐olds. Diffusion values were compared between groups and correlated with perinatal factors (gestational age, birthweight, and neonatal brain abnormalities) and neurodevelopmental outcomes (IQ, motor, academic, and behavioral outcomes) using Tract‐Based Spatial Statistics. Results: Compared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Neonatal brain abnormalities predicted lower FA and higher axon dispersion in many major tracts in VPT children. Lower FA, higher axon dispersion, and lower axon density in various tracts correlated with poorer neurodevelopmental outcomes in VPT children. Conclusions: FA and NODDI measures distinguished VPT children from controls and were associated with neonatal brain abnormalities and neurodevelopmental outcomes. This study provides a more detailed and biologically meaningful interpretation of white matter microstructure changes associated with prematurity. |
Keywords: | Magnetic resonance imaging; diffusion‐weighted imaging; diffusion tensor imaging; NODDI; white matter; neurodevelopment; preterm birth |
Rights: | © 2016 Wiley Periodicals, Inc. |
DOI: | 10.1002/hbm.23227 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/237117 http://purl.org/au-research/grants/nhmrc/491209 |
Published version: | http://dx.doi.org/10.1002/hbm.23227 |
Appears in Collections: | Aurora harvest 8 Dentistry publications |
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