Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/119359
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Genome-wide association study of an unusual dolphin mortality event reveals candidate genes for susceptibility and resistance to cetacean morbillivirus |
Author: | Batley, K.C. Sandoval-Castillo, J. Kemper, C.M. Attard, C.R.M. Zanardo, N. Tomo, I. Beheregaray, L.B. Möller, L.M. |
Citation: | Evolutionary Applications: evolutionary approaches to environmental, biomedical and socio-economic issues, 2019; 12(4):718-732 |
Publisher: | Wiley |
Issue Date: | 2019 |
ISSN: | 1752-4563 1752-4571 |
Statement of Responsibility: | Kimberley C. Batley, Jonathan Sandoval‐Castillo, Catherine M. Kemper, Catherine R. M. Attard, Nikki Zanardo, Ikuko Tomo, Luciano B. Beheregaray, Luciana M. Möller |
Abstract: | Infectious diseases are significant demographic and evolutionary drivers of populations, but studies about the genetic basis of disease resistance and susceptibility are scarce in wildlife populations. Cetacean morbillivirus (CeMV) is a highly contagious disease that is increasing in both geographic distribution and incidence, causing unusual mortality events (UME) and killing tens of thousands of individuals across multiple cetacean species worldwide since the late 1980s. The largest CeMV outbreak in the Southern Hemisphere reported to date occurred in Australia in 2013, where it was a major factor in a UME, killing mainly young Indo-Pacific bottlenose dolphins (Tursiops aduncus). Using cases (nonsurvivors) and controls (putative survivors) from the most affected population, we carried out a genome-wide association study to identify candidate genes for resistance and susceptibility to CeMV. The genomic data set consisted of 278,147,988 sequence reads and 35,493 high-quality SNPs genotyped across 38 individuals. Association analyses found highly significant differences in allele and genotype frequencies among cases and controls at 65 SNPs, and Random Forests conservatively identified eight as candidates. Annotation of these SNPs identified five candidate genes (MAPK8, FBXW11, INADL, ANK3 and ACOX3) with functions associated with stress, pain and immune responses. Our findings provide the first insights into the genetic basis of host defence to this highly contagious disease, enabling the development of an applied evolutionary framework to monitor CeMV resistance across cetacean species. Biomarkers could now be established to assess potential risk factors associated with these genes in other CeMV-affected cetacean populations and species. These results could also possibly aid in the advancement of vaccines against morbilliviruses. |
Keywords: | bottlenose dolphin cetacean morbillivirus ecological genomics genome-wide association study immune genes pathogen resistance virus wildlife disease |
Rights: | © 2018 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1111/eva.12747 |
Grant ID: | http://purl.org/au-research/grants/arc/FT130101068 |
Published version: | http://dx.doi.org/10.1111/eva.12747 |
Appears in Collections: | Aurora harvest 8 Dentistry publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_119359.pdf | Published Version | 1.11 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.