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https://hdl.handle.net/2440/120437
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Type: | Journal article |
Title: | Norbornene probes for the detection of cysteine sulfenic acid in cells |
Author: | Alcock, L.J. Oliveira, B.L. Deery, M.J. Pukala, T.L. Perkins, M.V. Bernardes, G.J.L. Chalker, J.M. |
Citation: | ACS Chemical Biology, 2019; 14(4):594-598 |
Publisher: | American Chemical Society |
Issue Date: | 2019 |
ISSN: | 1554-8929 1554-8937 |
Statement of Responsibility: | Lisa J. Alcock, Bruno L. Oliveira, Michael J. Deery, Tara L. Pukala, Michael V. Perkins, Gonçalo J. L. Bernardes and Justin M. Chalker |
Abstract: | Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone reagent. The norbornene probe also revealed a superior chemoselectivity when compared to a commonly used dimedone probe. Together, these results advance the study of cysteine oxidation in biological systems. |
Keywords: | Norbornanes Cysteine Sulfenic Acids Molecular Probes Oxidation-Reduction |
Rights: | © 2019 American Chemical Society |
DOI: | 10.1021/acschembio.8b01104 |
Grant ID: | http://purl.org/au-research/grants/arc/DE150101863 |
Published version: | http://dx.doi.org/10.1021/acschembio.8b01104 |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
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