Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/120513
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dc.contributor.author | Astria, E. | - |
dc.contributor.author | Thonhofer, M. | - |
dc.contributor.author | Ricco, R. | - |
dc.contributor.author | Liang, W. | - |
dc.contributor.author | Chemelli, A. | - |
dc.contributor.author | Tarzia, A. | - |
dc.contributor.author | Alt, K. | - |
dc.contributor.author | Hagemeyer, C.E. | - |
dc.contributor.author | Rattenberger, J. | - |
dc.contributor.author | Schroettner, H. | - |
dc.contributor.author | Wrodnigg, T. | - |
dc.contributor.author | Amenitsch, H. | - |
dc.contributor.author | Huang, D.M. | - |
dc.contributor.author | Doonan, C.J. | - |
dc.contributor.author | Falcaro, P. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Materials Horizons, 2019; 6(5):969-977 | - |
dc.identifier.issn | 2051-6347 | - |
dc.identifier.issn | 2051-6355 | - |
dc.identifier.uri | http://hdl.handle.net/2440/120513 | - |
dc.description.abstract | MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics. | - |
dc.description.statementofresponsibility | Efwita Astria, Martin Thonhofer … Weibin Liang … David M. Huang, Christian J. Doonan, Paolo Falcaro ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Royal Society of Chemistry | - |
dc.rights | Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. | - |
dc.source.uri | http://dx.doi.org/10.1039/c8mh01611a | - |
dc.title | Carbohydrates@MOFs | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1039/c8mh01611a | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP170103531 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/APP1078118 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/APP1098867 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Huang, D.M. [0000-0003-2048-4500] | - |
Appears in Collections: | Aurora harvest 4 Chemistry and Physics publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_120513.pdf | Published version | 4.7 MB | Adobe PDF | View/Open |
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