Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/121372
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Serum procalcitonin and C-reactive protein for differentiating bacterial infection from disease activity in patients with systemic lupus erythematosus |
Author: | Yu, J. Xu, B. Huang, Y. Zhao, J. Wang, S. Wang, H. Yang, N. |
Citation: | Modern Rheumatology, 2014; 24(3):457-463 |
Publisher: | Taylor & Francis |
Issue Date: | 2014 |
ISSN: | 1439-7595 1439-7609 |
Statement of Responsibility: | Jinquan Yu, Bingling Xu, Yuefang Huang, Jijun Zhao, Shuang Wang, Hongyue Wang and Niansheng Yang |
Abstract: | To study the clinical value of procalcitonin (PCT) and C-reactive protein (CRP) in differentiating bacterial infection from disease activity in systemic lupus erythematosus (SLE) patients.PCT and CRP in active SLE patients complicated with and without bacterial infection were retrospectively studied. Bacterial infection was diagnosed by positive culture results or typical symptoms and signs combined with positive response to antibiotics. Disease activity of SLE was assessed by systemic lupus erythematosus disease activity index (SLEDAI).One hundred and fourteen active SLE patients were recruited, 47 of which were with bacterial infection and 67 were non-infected. PCT and CRP levels were significantly elevated in patients with bacterial infection (P < 0.05). The ideal cutoff value for PCT was 0.38 ng/ml, at which the sensitivity (74.5%) and specificity (95.5%) combined the best. The negative predictive value and positive predictive value to detect bacterial infection were 84.2% and 92.1%, respectively. PCT but not the CRP level in the septic patients was significantly higher than that of non-septic ones. Meanwhile, in patients with SLEDAI score of > 10, both PCT and CRP levels were higher in patients with bacterial infection, but the difference was only statistically significant for PCT (P < 0.05). PCT was significantly reduced after anti-bacterial treatment.PCT test is superior to CRP test in detecting superimposed bacterial infection in active SLE patients. The levels of PCT are correlated with the severity of bacterial infection and can be used to monitor the response to antibiotic treatment. |
Keywords: | Bacterial infection; C-reactive protein; disease activity; procalcitonin; systemic lupus erythematosus |
Rights: | © 2014 Japan College of Rheumatology |
DOI: | 10.3109/14397595.2013.844391 |
Published version: | http://dx.doi.org/10.3109/14397595.2013.844391 |
Appears in Collections: | Aurora harvest 4 Environment Institute publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.