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https://hdl.handle.net/2440/121425
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Type: | Journal article |
Title: | Insights into DDT resistance from the Drosophila melanogaster Genetic Reference Panel |
Author: | Schmidt, J.M. Battlay, P. Gledhill-Smith, R.S. Good, R.T. Lumb, C. Fournier-Level, A. Robin, C. |
Citation: | Genetics: a periodical record of investigations bearing on heredity and variation, 2017; 207(3):1181-1193 |
Publisher: | Genetics Society of America |
Issue Date: | 2017 |
ISSN: | 0016-6731 1943-2631 |
Statement of Responsibility: | Joshua M. Schmidt, Paul Battlay, Rebecca S. Gledhill-Smith, Robert T. Good, Chris Lumb, Alexandre Fournier-Level, and Charles Robin |
Abstract: | Insecticide resistance is considered a classic model of microevolution, where a strong selective agent is applied to a large natural population, resulting in a change in frequency of alleles that confer resistance. While many insecticide resistance variants have been characterized at the gene level, they are typically single genes of large effect identified in highly resistant pest species. In contrast, multiple variants have been implicated in DDT resistance in Drosophila melanogaster; however, only the Cyp6g1 locus has previously been shown to be relevant to field populations. Here we use genome-wide association studies (GWAS) to identify DDT-associated polygenes and use selective sweep analyses to assess their adaptive significance. We identify and verify two candidate DDT resistance loci. A largely uncharacterized gene, CG10737, has a function in muscles that ameliorates the effects of DDT, while a putative detoxifying P450, Cyp6w1, shows compelling evidence of positive selection. |
Keywords: | Drosophila Genetic Reference Panel (DGRP); DDT; CG10737; Cyp6w1; triallele |
Rights: | Copyright © 2017 by the Genetics Society of America |
DOI: | 10.1534/genetics.117.300310 |
Grant ID: | http://purl.org/au-research/grants/arc/DP0985013 |
Published version: | http://dx.doi.org/10.1534/genetics.117.300310 |
Appears in Collections: | Aurora harvest 4 Genetics publications |
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