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https://hdl.handle.net/2440/12153
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dc.contributor.author | Wegener, K. | - |
dc.contributor.author | Wabnitz, P. | - |
dc.contributor.author | Carver, J. | - |
dc.contributor.author | Bowie, J. | - |
dc.contributor.author | Chia, B. | - |
dc.contributor.author | Wallace, J. | - |
dc.contributor.author | Tyler, M. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | The Federation of European Biochemical Societies (FEBS) Journal, 1999; 265(2):627-637 | - |
dc.identifier.issn | 0014-2956 | - |
dc.identifier.issn | 1432-1033 | - |
dc.identifier.uri | http://hdl.handle.net/2440/12153 | - |
dc.description.abstract | Nineteen citropin peptides are present in the secretion from the granular dorsal glands of the Blue Mountains tree-frog Litoria citropa; 15 of these peptides are also present in the secretion from the submental gland. Two major peptides, citropin 1.1 (GLFDVIKKVASVIGGL-NH2), citropin 1.2 (GLFDIIKKVASVVGGL-NH2) and a minor peptide, citropin 1.3 (GLFDIIKKVASVIGGL-NH2) are wide-spectrum antibacterial peptides. The amphibian has an endoprotease which deactivates these membrane-active peptides by removing residues from the N-terminal end: loss of three residues gives the most abundant degradation products. The solution structure of the basic peptide citropin 1.1 has been determined by NMR spectroscopy [in a solvent mixture of trifluoroethanol/water (1 : 1)] to be an amphipathic alpha-helix with well-defined hydrophobic and hydrophilic regions. The additional four peptides produced by the dorsal glands are structurally related to the antibacterial citropin 1 peptides but contain three more residues at their C-terminus [e.g. citropin 1.1.3 (GLFDVIKKVASVIGLASP-OH)]. These peptides show minimal antibacterial activity; their role in the amphibian skin is not known. | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.source.uri | http://dx.doi.org/10.1046/j.1432-1327.1999.00750.x | - |
dc.subject | Skin | - |
dc.subject | Animals | - |
dc.subject | Anura | - |
dc.subject | Peptides | - |
dc.subject | Antimicrobial Cationic Peptides | - |
dc.subject | Proteins | - |
dc.subject | Amphibian Proteins | - |
dc.subject | Anti-Infective Agents | - |
dc.subject | Circular Dichroism | - |
dc.subject | Magnetic Resonance Spectroscopy | - |
dc.subject | Sequence Analysis | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Models, Molecular | - |
dc.subject | Molecular Sequence Data | - |
dc.subject | Mass Spectrometry | - |
dc.title | Host defence peptides from the skin glands of the Australian Blue Mountains tree-frog Litoria citropa | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1046/j.1432-1327.1999.00750.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wegener, K. [0000-0002-1562-6060] | - |
Appears in Collections: | Aurora harvest 7 Ecology, Evolution and Landscape Science publications |
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