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https://hdl.handle.net/2440/121708
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dc.contributor.author | Mc Pherson, N.O. | - |
dc.contributor.author | Shehadeh, H. | - |
dc.contributor.author | Fullston, T. | - |
dc.contributor.author | Zander-Fox, D. | - |
dc.contributor.author | Lane, M. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nutrients, 2019; 11(9):1-18 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2440/121708 | - |
dc.description.abstract | Male obesity, which often co-presents with micronutrient deficiencies, is associated with sub-fertility. Here we investigate whether short-term dietary supplementation of micronutrients (zinc, selenium, lycopene, vitamins E and C, folic acid, and green tea extract) to obese mice for 12 days (designed to span the epididymal transit) could improve sperm quality and fetal outcomes. Five-week-old C57BL6 males were fed a control diet (CD, n = 24) or high fat diet (HFD, n = 24) for 10 weeks before allocation to the 12-day intervention of maintaining their original diets (CD, n = 12, HFD n = 12) or with micronutrient supplementation (CD + S, n = 12, HFD + S, n = 12). Measures of sperm quality (motility, morphology, capacitation, binding), sperm oxidative stress (DCFDA, MSR, and 8OHdG), early embryo development (2-cell cleavage, 8OHdG), and fetal outcomes were assessed. HFD + S males had reduced sperm intracellular reactive oxygen species (ROS) concentrations and 8OHdG lesions, which resulted in reduced 8OHdG lesions in the male pronucleus, increased 2-cell cleavage rates, and partial restoration of fetal weight similar to controls. Sub-fertility associated with male obesity may be restored with very short-term micronutrient supplementation that targets the timing of the transit of sperm through the epididymis, which is the developmental window where sperm are the most susceptible to oxidative damage. | - |
dc.description.statementofresponsibility | Nicole O. McPherson, Helana Shehadeh, Tod Fullston, Deirdre L. Zander-Fox and Michelle Lane | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.source.uri | http://dx.doi.org/10.3390/nu11092196 | - |
dc.subject | Spermatozoa | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Mice | - |
dc.subject | Mice, Obese | - |
dc.subject | Infertility, Male | - |
dc.subject | Obesity | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Micronutrients | - |
dc.subject | Sperm Motility | - |
dc.subject | Oxidative Stress | - |
dc.subject | Embryonic Development | - |
dc.subject | Dietary Supplements | - |
dc.subject | Male | - |
dc.subject | Diet, High-Fat | - |
dc.title | Dietary micronutrient supplementation for 12 days in obese male mice restores sperm oxidative stress | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.3390/nu11092196 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mc Pherson, N.O. [0000-0002-3492-9403] | - |
dc.identifier.orcid | Fullston, T. [0000-0003-1314-3038] | - |
Appears in Collections: | Aurora harvest 4 Genetics publications |
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