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https://hdl.handle.net/2440/121904
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dc.contributor.author | Potts, K.S. | - |
dc.contributor.author | Sargeant, T.J. | - |
dc.contributor.author | Markham, J.F. | - |
dc.contributor.author | Shi, W. | - |
dc.contributor.author | Biben, C. | - |
dc.contributor.author | Josefsson, E.C. | - |
dc.contributor.author | Whitehead, L.W. | - |
dc.contributor.author | Rogers, K.L. | - |
dc.contributor.author | Liakhovitskaia, A. | - |
dc.contributor.author | Smyth, G.K. | - |
dc.contributor.author | Kile, B.T. | - |
dc.contributor.author | Medvinsky, A. | - |
dc.contributor.author | Alexander, W.S. | - |
dc.contributor.author | Hilton, D.J. | - |
dc.contributor.author | Taoudi, S. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Blood, 2014; 124(17):2725-2729 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | http://hdl.handle.net/2440/121904 | - |
dc.description.abstract | In this study, we test the assumption that the hematopoietic progenitor/colony-forming cells of the embryonic yolk sac (YS), which are endowed with megakaryocytic potential, differentiate into the first platelet-forming cells in vivo. We demonstrate that from embryonic day (E) 8.5 all megakaryocyte (MK) colony-forming cells belong to the conventional hematopoietic progenitor cell (HPC) compartment. Although these cells are indeed capable of generating polyploid MKs, they are not the source of the first platelet-forming cells. We show that proplatelet formation first occurs in a unique and previously unrecognized lineage of diploid platelet-forming cells, which develop within the YS in parallel to HPCs but can be specified in the E8.5 Runx1-null embryo despite the absence of the progenitor cell lineage. | - |
dc.description.statementofresponsibility | Kathryn S. Potts, Tobias J. Sargeant, John F. Markham, Wei Shi, Christine Biben ... Benjamin T. Kile ... et al. | - |
dc.language.iso | en | - |
dc.publisher | American Society of Hematology | - |
dc.rights | © 2014 by The American Society of Hematology. | - |
dc.source.uri | http://dx.doi.org/10.1182/blood-2014-02-559468 | - |
dc.subject | Megakaryocytes | - |
dc.title | A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1182/blood-2014-02-559468 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/1016647 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/361646 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kile, B.T. [0000-0002-8836-8947] | - |
Appears in Collections: | Aurora harvest 4 Medical Sciences publications |
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