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https://hdl.handle.net/2440/123292
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Type: | Journal article |
Title: | Short-term (48 hours) intravenous serelaxin infusion has no effect on myogenic tone or vascular remodeling in rat mesenteric arteries |
Author: | Jelinic, M. Leo, C.H. Marshall, S.A. Senadheera, S.N. Parry, L.J. Tare, M. |
Citation: | Microcirculation, 2017; 24(6):e12371-1-e12371-12 |
Publisher: | Wiley |
Issue Date: | 2017 |
ISSN: | 1073-9688 1549-8719 |
Statement of Responsibility: | Maria Jelinic, Chen Huei Leo, Sarah A. Marshall, Sevvandi N. Senadheera, Laura J. Parry, Marianne Tare |
Abstract: | Background: Short-term IV sRLX (recombinant human relaxin-2) infusion enhances endothelium-dependent relaxation in mesenteric arteries. This is initially underpinned by increased NO followed by a transition to prostacyclin. The effects of short-term IV sRLX treatment on pressure-induced myogenic tone and vascular remodeling in these arteries are unknown. Therefore, we investigated the effects of sRLX infusion on pressure-induced myogenic tone and passive mechanical wall properties in mesenteric arteries. Methods: Mesenteric artery myogenic tone and passive mechanics were examined after 48-hours and 10-days infusion of sRLX. Potential mechanisms of action were assessed by pressure myography, qPCR, and Western blot analysis. Results: Neither 48-hours nor 10-days sRLX treatment had significant effects on myogenic tone, passive arterial wall stiffness, volume compliance, or axial lengthening. However, in 48-hours sRLX -treated rats, incubation with the NO synthase blocker L-NAME significantly increased myogenic tone (P<.05 vs placebo), demonstrating an increased contribution of NO to the regulation of myogenic tone. eNOS dimerization, but not phosphorylation, was significantly upregulated in the arteries of sRLX -treated rats. Conclusion: In mesenteric arteries, 48-hours sRLX treatment upregulates the role of NO in the regulation of myogenic tone by enhancing eNOS dimerization, without altering overall myogenic tone or vascular remodeling. |
Keywords: | Myogenic tone; nitric oxide; relaxin; vascular stiffness |
Rights: | © 2017 John Wiley & Sons Ltd |
DOI: | 10.1111/micc.12371 |
Grant ID: | http://purl.org/au-research/grants/arc/LP110200543 |
Published version: | http://dx.doi.org/10.1111/micc.12371 |
Appears in Collections: | Aurora harvest 4 Pharmacology publications |
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