Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/126141
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Understanding skin absorption of common aldehyde vapours from exposure during hazardous material incidents |
Author: | Thredgold, L. Gaskin, S. Heath, L. Pisaniello, D. Logan, M. Baxter, C. |
Citation: | Journal of Exposure Science and Environmental Epidemiology, 2019; 30(3):537-546 |
Publisher: | Springer Nature |
Issue Date: | 2019 |
ISSN: | 1559-0631 1559-064X |
Statement of Responsibility: | Leigh Thredgold, Sharyn Gaskin, Linda Heath, Dino Pisaniello, Michael Logan, Christina Baxter |
Abstract: | The toxic release of aldehyde vapours during a hazardous material (HAZMAT) incident primarily results in respiratory concerns for the unprotected public. However, skin absorption may be an important concurrent exposure route that is poorly understood for this scenario. This study provides experimental data on the skin absorption properties of common aldehydes used in industry, including acetaldehyde, acrolein, benzaldehyde and formaldehyde, in gaseous or vapour form using an adapted in vitro technique. Two of the four tested aldehydes were found to penetrate the skin in appreciable amounts following 30-min exposure at HAZMAT relevant atmospheric concentrations: acetaldehyde (5.29 ± 3.24 μg/cm²) and formaldehyde (3.45 ± 2.58 μg/cm²). Whereas only low levels of acrolein (0.480 ± 0.417 μg/cm²) and benzaldehyde (1.46 ± 0.393 μg/cm²) skin penetration was noted. The aldehydes demonstrated differing levels of interaction with fabric. Formaldehyde and acetaldehyde adsorbed strongly to denim, whereas benzaldehyde and acrolein displayed no sink properties. However, denim was shown to be an initial protective barrier and reduced penetration outcomes for all aldehydes. This study provides important information to assist first responders and confirms the relevance of using physicochemical properties (e.g. solubility, molecular weight, partition coefficient) to predict skin permeation potential in the absence of empirical data during HAZMAT incidents involving different types of aldehydes. |
Keywords: | Dermal exposure; Aldehydes; Vapour; In vitro; HAZMAT |
Description: | Published online: 15 February 2019 |
Rights: | © Springer Nature America, Inc. 2019 |
DOI: | 10.1038/s41370-019-0127-4 |
Published version: | http://dx.doi.org/10.1038/s41370-019-0127-4 |
Appears in Collections: | Aurora harvest 8 Public Health publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_126141.pdf | Accepted version | 975.28 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.