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https://hdl.handle.net/2440/128306
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dc.contributor.author | Murthy, A.M.V. | - |
dc.contributor.author | Robinson, N. | - |
dc.contributor.author | Kumar, S. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Cell Death and Differentiation, 2020; 27(11):2989-3003 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.issn | 1476-5403 | - |
dc.identifier.uri | http://hdl.handle.net/2440/128306 | - |
dc.description | Published online: 18 September 2020 | - |
dc.description.abstract | Cytosolic nucleic acid sensors have a critical role in detecting endogenous nucleic acids to initiate innate immune responses during microbial infections and/or cell death. Several seminal studies over the past decade have delineated the conserved mechanism of cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and the downstream signaling adapter stimulator of interferon genes (STING) in mediating innate immune signaling pathways as a host defense mechanism. Besides the predominant role in microbial infections and inflammatory diseases, there is an increased attention on alternative functional responses of cGAS-STING-mediated signaling. Here we review the complexity of interactions between the cGAS-STING signaling and cell death pathways. A better understanding of molecular mechanisms of this interplay is important with regard to the development of new therapeutics targeting cGAS-STING signaling in cancer, infectious, and chronic inflammatory diseases. | - |
dc.description.statementofresponsibility | Ambika M. V. Murthy, Nirmal Robinson and Sharad Kumar | - |
dc.language.iso | en | - |
dc.publisher | Springer Nature | - |
dc.rights | © The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020 | - |
dc.source.uri | http://dx.doi.org/10.1038/s41418-020-00624-8 | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Neoplasms | - |
dc.subject | Disease Susceptibility | - |
dc.subject | Nucleotidyltransferases | - |
dc.subject | Membrane Proteins | - |
dc.subject | Signal Transduction | - |
dc.subject | Cell Death | - |
dc.subject | Immunity, Innate | - |
dc.subject | Infections | - |
dc.title | Crosstalk between cGAS-STING signaling and cell death | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/s41418-020-00624-8 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1103006 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1144500 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1156601 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Robinson, N. [0000-0002-7361-9491] | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest 8 Biochemistry publications |
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