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https://hdl.handle.net/2440/128905
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Type: | Book chapter |
Title: | Paternal obesity and programming of offspring health |
Author: | Fullston, T. Shehadeh, H. Schjenken, J.E. McPherson, N.O. Robertson, S.A. Zander-Fox, D. Lane, M. |
Citation: | Parental Obesity: Intergenerational Programming and Consequences, 2016 / Green, L.R., Hester, R.L. (ed./s), Ch.6, pp.105-131 |
Publisher: | Springer |
Publisher Place: | New York, NY |
Issue Date: | 2016 |
Series/Report no.: | Physiology in Health and Disease |
ISBN: | 1493963848 9781493963843 |
Editor: | Green, L.R. Hester, R.L. |
Statement of Responsibility: | Tod Fullston, Helana S. Shehadeh, John E. Schjenken, Nicole O. McPherson, Sarah A. Robertson, Deirdre Zander-Fox, and Michelle Lane |
Abstract: | The physical and nutritional environment experienced by the mother prior to and during conception is imperative to the outcome of pregnancy and offspring health. In addition there is now mounting evidence that paternal exposures and conditions at the time of conception are also an important determinant of pregnancy outcome and offspring health. Specifically, male obesity is now demonstrated to have detrimental impacts on fertility and fetal development during subsequent pregnancy and can exert programming effects on the phenotype of offspring lasting up to two generations. We summarise the evidence of the effect of environmental exposures on seminal plasma and sperm, focusing on the effects of obesity, and what bearing this has for offspring both in humans and animal models. The current knowledge of what might form the molecular basis of the phenomena of paternal programming of offspring health are also reviewed with consideration given to signals from both seminal plasma and sperm. |
Rights: | © The American Physiological Society 2016 |
DOI: | 10.1007/978-1-4939-6386-7_6 |
Published version: | https://link.springer.com/book/10.1007%2F978-1-4939-6386-7 |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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