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https://hdl.handle.net/2440/130646
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dc.contributor.author | Grace, E. | - |
dc.contributor.author | Hilditch, C. | - |
dc.contributor.author | Gomersall, J. | - |
dc.contributor.author | Collins, C.T. | - |
dc.contributor.author | Rumbold, A. | - |
dc.contributor.author | Keir, A.K. | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Archives of Disease in Childhood: Fetal and Neonatal Edition, 2021; 106(2):142-137 | - |
dc.identifier.issn | 1359-2998 | - |
dc.identifier.issn | 1468-2052 | - |
dc.identifier.uri | http://hdl.handle.net/2440/130646 | - |
dc.description.abstract | OBJECTIVE:To conduct a systematic review and meta-analysis of the efficacy and safety of fortification of human milk with human milk-based fortifier versus cow's milk-based fortifier for use in preterm and/or very low birthweight infants. DESIGN:Randomised or quasi-randomised controlled trials comparing the effect of human milk fortification with human milk-based milk fortifier versus cow's milk-based fortifier in infants born <34 weeks' gestation and/or with birth weight <1500 g were identified by searching databases, clinical trial registries and reference lists until 5 November 2019. Two authors independently extracted data and assessed evidence quality. Meta-analyses were conducted using fixed or random effects models, as appropriate. MAIN OUTCOME MEASURES:Necrotising enterocolitis (Bell's stage II or higher) and late-onset sepsis. RESULTS:Of 863 unique records identified, 16 full-text trials were screened and 2 trials involving 334 infants were included. Primary outcome data were available for 332 infants. Use of human milk-based fortifier compared with cow's milk-based fortifier reduced the risk of necrotising enterocolitis (risk ratio 0.47, 95% CI 0.22 to 0.98). There was no clear evidence of an effect on late-onset sepsis or any other outcomes. The quality of evidence was low to very low due to imprecision and lack of blinding in one study. CONCLUSIONS:Findings suggest that there is a reduction in the incidence of necrotising enterocolitis with human milk-based fortifiers compared with cow's milk-based fortifiers. The overall quality of evidence is low. Further appropriately powered trials are required before this intervention can be routinely recommended for preterm infants. | - |
dc.description.statementofresponsibility | Erin Grace, Cathie Hilditch, Judith Gomersall, Carmel T Collins, Alice Rumbold, Amy K Keir ... et al. | - |
dc.language.iso | en | - |
dc.publisher | BMJ | - |
dc.rights | © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. | - |
dc.source.uri | http://dx.doi.org/10.1136/archdischild-2020-319406 | - |
dc.subject | mortality | - |
dc.subject | neonatology | - |
dc.title | Safety and efficacy of human milk-based fortifier in enterally fed preterm and/or low birthweight infants: a systematic review and meta-analysis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1136/archdischild-2020-319406 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1161379 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1132596 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Grace, E. [0000-0002-6366-9284] | - |
dc.identifier.orcid | Hilditch, C. [0000-0002-4548-987X] | - |
dc.identifier.orcid | Gomersall, J. [0000-0002-9148-7162] | - |
dc.identifier.orcid | Collins, C.T. [0000-0003-3308-9948] | - |
dc.identifier.orcid | Rumbold, A. [0000-0002-4453-9425] | - |
dc.identifier.orcid | Keir, A.K. [0000-0003-1692-5676] | - |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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