Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/130821
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma |
Author: | Meakin, A.S. Morrison, J.L. Bradshaw, E.L. Holman, S.L. Saif, Z. Gatford, K.L. Wallace, M.J. Bischof, R.J. Moss, T.J.M. Clifton, V.L. |
Citation: | Placenta, 2021; 104:232-235 |
Publisher: | Elsevier BV |
Issue Date: | 2021 |
ISSN: | 0143-4004 1532-3102 |
Statement of Responsibility: | Ashley S. Meakin, Janna L. Morrison, Emma L. Bradshaw, Stacey L. Holman, Zarqa Saif, Kathryn L. Gatford, Megan J. Wallace, Robert J. Bischof, Timothy J.M. Moss, Vicki L. Clifton |
Abstract: | Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development. |
Keywords: | Androgen; androgen receptor; sheep; asthma |
Rights: | Crown Copyright © 2021 Published by Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.placenta.2021.01.003 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1043294 http://purl.org/au-research/grants/nhmrc/1041918 http://purl.org/au-research/grants/nhmrc/1136100 http://purl.org/au-research/grants/nhmrc/1066916 http://purl.org/au-research/grants/arc/FT170100431 |
Published version: | http://dx.doi.org/10.1016/j.placenta.2021.01.003 |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.