Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/132107
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Genders, S.G. | - |
dc.contributor.author | Scheller, K.J. | - |
dc.contributor.author | Jaehne, E.J. | - |
dc.contributor.author | Turner, B.J. | - |
dc.contributor.author | Lawrence, A.J. | - |
dc.contributor.author | Brunner, S.M. | - |
dc.contributor.author | Kofler, B. | - |
dc.contributor.author | van den Buuse, M. | - |
dc.contributor.author | Djouma, E. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Addiction Biology, 2019; 24(5):886-897 | - |
dc.identifier.issn | 1355-6215 | - |
dc.identifier.issn | 1369-1600 | - |
dc.identifier.uri | https://hdl.handle.net/2440/132107 | - |
dc.description.abstract | Galanin is a neuropeptide which mediates its effects via three G-protein coupled receptors (GAL₃ ). Administration of a GAL₃ antagonist reduces alcohol self-administration in animal models while allelic variation in the GAL₃ gene has been associated with an increased risk of alcohol use disorders in diverse human populations. Based on the association of GAL₃ with alcoholism, we sought to characterize drug-seeking behavior in GAL₃ -deficient mice for the first time. In the two-bottle free choice paradigm, GAL₃ -KO mice consistently showed a significantly increased preference for ethanol over water when compared to wildtype littermates. Furthermore, male GAL₃ -KO mice displayed significantly increased responding for ethanol under operant conditions. These differences in alcohol seeking behavior in GAL₃ -KO mice did not result from altered ethanol metabolism. In contrast to ethanol, GAL₃ -KO mice exhibited similar preference for saccharin and sucrose over water, and a similar preference for a high fat diet over a low fat diet as wildtype littermates. No differences in cognitive and locomotor behaviors were observed in GAL₃ -KO mice to account for increased alcohol seeking behavior. Overall, these findings suggest genetic ablation of GAL₃ in mice increases alcohol consumption. | - |
dc.description.statementofresponsibility | Shannyn G. Genders, Karlene J. Scheller, Emily J. Jaehne, Bradley J. Turner, Andrew J. Lawrence, Susanne M. Brunner ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2018 Society for the Study of Addiction | - |
dc.source.uri | http://dx.doi.org/10.1111/adb.12641 | - |
dc.subject | Addiction; alcohol; galanin; galanin receptor-3 | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Mice, Knockout | - |
dc.subject.mesh | Hyperkinesis | - |
dc.subject.mesh | Ethanol | - |
dc.subject.mesh | Methamphetamine | - |
dc.subject.mesh | Apomorphine | - |
dc.subject.mesh | Dizocilpine Maleate | - |
dc.subject.mesh | Receptor, Galanin, Type 3 | - |
dc.subject.mesh | Dopamine Agonists | - |
dc.subject.mesh | Excitatory Amino Acid Antagonists | - |
dc.subject.mesh | Central Nervous System Depressants | - |
dc.subject.mesh | Central Nervous System Stimulants | - |
dc.subject.mesh | Self Administration | - |
dc.subject.mesh | Alcohol Drinking | - |
dc.subject.mesh | Motor Activity | - |
dc.subject.mesh | Emotions | - |
dc.subject.mesh | Fear | - |
dc.subject.mesh | Interpersonal Relations | - |
dc.subject.mesh | Conditioning, Operant | - |
dc.subject.mesh | Maze Learning | - |
dc.subject.mesh | Choice Behavior | - |
dc.subject.mesh | Phenotype | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Male | - |
dc.subject.mesh | Sensory Gating | - |
dc.subject.mesh | Drug-Seeking Behavior | - |
dc.subject.mesh | Reflex, Startle | - |
dc.subject.mesh | Spatial Memory | - |
dc.title | GAL₃ receptor knockout mice exhibit an alcohol-preferring phenotype | - |
dc.title.alternative | GAL(3) receptor knockout mice exhibit an alcohol-preferring phenotype | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/adb.12641 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1137024 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Jaehne, E.J. [0000-0003-0532-1623] | - |
Appears in Collections: | Biochemistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.