Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/132953
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jamieson, L.M. | - |
dc.contributor.author | Garvey, G. | - |
dc.contributor.author | Hedges, J. | - |
dc.contributor.author | Leane, C. | - |
dc.contributor.author | Hill, I. | - |
dc.contributor.author | Brown, A. | - |
dc.contributor.author | Ju, X. | - |
dc.contributor.author | Sethi, S. | - |
dc.contributor.author | Roder, D. | - |
dc.contributor.author | Logan, R.M. | - |
dc.contributor.author | Johnson, N. | - |
dc.contributor.author | Smith, M. | - |
dc.contributor.author | Antonsson, A. | - |
dc.contributor.author | Canfell, K. | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | BMJ Open, 2021; 11(6):e046928-1-e046928-11 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.uri | https://hdl.handle.net/2440/132953 | - |
dc.description.abstract | Purpose Our aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-related health state valuations and; (4) determine the impact on OPSCC and cervical cancers, and the cost-effectiveness of extending publicly-funded HPV vaccination among Indigenous Australians. Participants Participants were recruited from February 2018 to January 2019. Twelve-month follow-up occurred from March 2019 to March 2020. Participants provided socio-demographic characteristics, health-related behaviours including tobacco and alcohol use and sexual history. Health state preferences in regard to HPV vaccination, knowledge regarding HPV infection, OPSCC and cervical cancer were collected using a two-stage standard gamble approach. Participants provided saliva samples and DNA for microbial genotyping was extracted. Findings to date Of the 910 participants who were positive for β-globin at baseline, 35% had any oral HPV infection. The most prevalent HPV types were 13 or 32 (Heck’s disease; 23%). The second most prevalent types were associated with OPSCC (HPV 16 or 18; 3.3%). Of the 645 participants who were positive for β-globin at 12-month follow-up, 43% had any HPV infection. Of these, 33% were HPV types 13 or 32 and 2.5% were HPV 16 or 18. Some 588 participants had β-globin positive oral samples at baseline and 12-month follow-up. The prevalence of any oral HPV infection increased from 34% at baseline to 44% at 12-month follow-up; due to increases in HPV types 13 or 32 (20% at baseline and 34% at 12-month follow-up). Future plans Further funding will be sought to continue follow-up of this cohort, and to include (after a full medical history) a thorough clinical examination of the external head and neck; a complete oral examination and examination of the oropharynx. Blood tests for early stage OPSCC will also be undertaken. | - |
dc.description.statementofresponsibility | Lisa M Jamieson, Gail Garvey, Joanne Hedges, Cathy Leane, Isaac Hill, Alex Brown ... et al. | - |
dc.language.iso | en | - |
dc.publisher | BMJ | - |
dc.rights | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | - |
dc.source.uri | https://www.bmj.com/ | - |
dc.subject | Humans | - |
dc.subject | Papillomaviridae | - |
dc.subject | Papillomavirus Infections | - |
dc.subject | Carcinoma, Squamous Cell | - |
dc.subject | Head and Neck Neoplasms | - |
dc.subject | Oropharyngeal Neoplasms | - |
dc.subject | Prospective Studies | - |
dc.subject | Australia | - |
dc.subject | Female | - |
dc.subject | Alphapapillomavirus | - |
dc.subject | Squamous Cell Carcinoma of Head and Neck | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Papillomaviridae | - |
dc.subject.mesh | Papillomavirus Infections | - |
dc.subject.mesh | Carcinoma, Squamous Cell | - |
dc.subject.mesh | Head and Neck Neoplasms | - |
dc.subject.mesh | Oropharyngeal Neoplasms | - |
dc.subject.mesh | Prospective Studies | - |
dc.subject.mesh | Australia | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Alphapapillomavirus | - |
dc.subject.mesh | Squamous Cell Carcinoma of Head and Neck | - |
dc.title | Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1136/bmjopen-2020-046928 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1120215 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1102587 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1159491 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1176651 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Jamieson, L.M. [0000-0001-9839-9280] | - |
dc.identifier.orcid | Hedges, J. [0000-0002-2413-5992] | - |
dc.identifier.orcid | Brown, A. [0000-0003-2112-3918] | - |
dc.identifier.orcid | Ju, X. [0000-0003-4759-3918] | - |
dc.identifier.orcid | Sethi, S. [0000-0002-3571-5298] | - |
dc.identifier.orcid | Roder, D. [0000-0001-6442-4409] | - |
dc.identifier.orcid | Logan, R.M. [0000-0002-9331-1814] | - |
Appears in Collections: | Public Health publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_132953.pdf | Published version | 592.45 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.