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https://hdl.handle.net/2440/133042
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Type: | Journal article |
Title: | Eradication of mature bacterial biofilms with concurrent improvement in chronic wound healing using silver nanoparticle hydrogel treatment |
Author: | Haidari, H. Bright, R. Garg, S. Vasilev, K. Cowin, A.J. Kopecki, Z. |
Citation: | Biomedicines, 2021; 9(9):1182-1-1182-20 |
Publisher: | MDPI |
Issue Date: | 2021 |
ISSN: | 2227-9059 2227-9059 |
Statement of Responsibility: | Hanif Haidari, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin and Zlatko Kopecki |
Abstract: | Biofilm-associated infections are a major cause of impaired wound healing. Despite the broad spectrum of anti-bacterial benefits provided by silver nanoparticles (AgNPs), these materials still cause controversy due to cytotoxicity and a lack of efficacy against mature biofilms. Herein, highly potent ultrasmall AgNPs were combined with a biocompatible hydrogel with integrated synergistic functionalities to facilitate elimination of clinically relevant mature biofilms in-vivo combined with improved wound healing capacity. The delivery platform showed a superior release mechanism, reflected by high biocompatibility, hemocompatibility, and extended antibacterial efficacy. In vivo studies using the S. aureus wound biofilm model showed that the AgNP hydrogel (200 µg/g) was highly effective in eliminating biofilm infection and promoting wound repair compared to the controls, including silver sulfadiazine (Ag SD). Treatment of infected wounds with the AgNP hydrogel resulted in faster wound closure (46% closure compared to 20% for Ag SD) and accelerated wound re-epithelization (60% for AgNP), as well as improved early collagen deposition. The AgNP hydrogel did not show any toxicity to tissue and/or organs. These findings suggest that the developed AgNP hydrogel has the potential to be a safe wound treatment capable of eliminating infection and providing a safe yet effective strategy for the treatment of infected wounds. |
Keywords: | Wound infection; antibiofilm hydrogel; AgNP hydrogel; stimuli responsive hydrogel; wound healing; controlled release; wound biofilm eradication; mature biofilm |
Rights: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
DOI: | 10.3390/biomedicines9091182 |
Grant ID: | http://purl.org/au-research/grants/arc/DP15104212 http://purl.org/au-research/grants/nhmrc/1122825 http://purl.org/au-research/grants/nhmrc/1032738 http://purl.org/au-research/grants/nhmrc/1102617 |
Published version: | http://dx.doi.org/10.3390/biomedicines9091182 |
Appears in Collections: | Biochemistry publications |
Files in This Item:
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hdl_133042.pdf | Published version | 9.3 MB | Adobe PDF | View/Open |
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