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https://hdl.handle.net/2440/133141
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dc.contributor.author | Black, L.J. | - |
dc.contributor.author | Baker, K. | - |
dc.contributor.author | Ponsonby, A.L. | - |
dc.contributor.author | Van Der Mei, I. | - |
dc.contributor.author | Lucas, R.M. | - |
dc.contributor.author | Pereira, G. | - |
dc.contributor.author | Chapman, C. | - |
dc.contributor.author | Coulthard, A. | - |
dc.contributor.author | Dear, K. | - |
dc.contributor.author | Dwyer, T. | - |
dc.contributor.author | Kilpatrick, T. | - |
dc.contributor.author | McMichael Dec, T. | - |
dc.contributor.author | Pender, M.P. | - |
dc.contributor.author | Taylor, B. | - |
dc.contributor.author | Valery, P. | - |
dc.contributor.author | Williams, D. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | The Journal of Nutrition, 2019; 149(8):1385-1392 | - |
dc.identifier.issn | 0022-3166 | - |
dc.identifier.issn | 1541-6100 | - |
dc.identifier.uri | https://hdl.handle.net/2440/133141 | - |
dc.description.abstract | BACKGROUND:The evidence associating diet and risk of multiple sclerosis (MS) is inconclusive. OBJECTIVES:The aim of this study was to investigate associations between a Mediterranean diet and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS. METHODS:We used data from the 2003-2006 Ausimmune Study, an Australian multicenter, case-control study examining environmental risk factors for FCD, with participants matched on age, sex, and study region (282 cases, 558 controls; 18-59 y old; 78% female). The alternate Mediterranean diet score (aMED) was calculated based on data from a food-frequency questionnaire. We created a modified version of the aMED (aMED-Red) where ∼1 daily serving (65 g) of unprocessed red meat received 1 point. All other components remained the same as aMED. Conditional logistic regression (254 cases, 451 controls) was used to test associations between aMED and aMED-Red scores and categories and risk of FCD, adjusting for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, education, total energy intake, and dietary underreporting. RESULTS:There was no statistically significant association between aMED and risk of FCD [per 1-SD increase in aMED score: adjusted odds ratio (aOR): 0.89; 95% CI: 0.75, 1.06; P = 0.181]. There was evidence of a nonlinear relation between aMED-Red and risk of FCD when a quadratic term was used (P = 0.016). Compared with the lowest category of aMED-Red, higher categories were significantly associated with reduced risk of FCD, corresponding to a 37% (aOR: 0.63; 95% CI: 0.41, 0.98; P = 0.039), 52% (aOR: 0.48; 95% CI: 0.28, 0.83; P = 0.009), and 42% (aOR: 0.58; 95% CI: 0.35, 0.96; P = 0.034) reduced risk of FCD in categories 2, 3, and 4, respectively. CONCLUSIONS:A Mediterranean diet, including unprocessed red meat, was associated with reduced risk of FCD in this Australian adult population. The addition of unprocessed red meat to a Mediterranean diet may be beneficial for those at high risk of MS. | - |
dc.description.statementofresponsibility | Lucinda J Black, Kimberley Baker, Anne-Louise Ponsonby, Ingrid van der Mei, Robyn M Lucas, Gavin Pereira, Ausimmune Investigator Group | - |
dc.language.iso | en | - |
dc.publisher | American Society for Nutrition | - |
dc.rights | © American Society for Nutrition 2019. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1093/jn/nxz089 | - |
dc.subject | Ausimmune Investigator Group | - |
dc.subject | Multiple sclerosis; Mediterranean diet; Ausimmune Study; nutrition and disease; nutritional epidemiology | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Central Nervous System Diseases | - |
dc.subject.mesh | Demyelinating Diseases | - |
dc.subject.mesh | Case-Control Studies | - |
dc.subject.mesh | Diet, Mediterranean | - |
dc.subject.mesh | Adult | - |
dc.subject.mesh | Middle Aged | - |
dc.subject.mesh | Australia | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Male | - |
dc.subject.mesh | Red Meat | - |
dc.title | A higher mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of australian adults | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/jn/nxz089 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Dear, K. [0000-0002-0788-7404] | - |
Appears in Collections: | Public Health publications |
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