Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/133217
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation |
Author: | Han, F.Y. Liu, Y. Kumar, V. Xu, W. Yang, G. Zhao, C.X. Woodruff, T.M. Whittaker, A.K. Smith, M.T. |
Citation: | International Journal of Pharmaceutics, 2020; 581:119291-1-119291-7 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 0378-5173 1873-3476 |
Statement of Responsibility: | Felicity Y. Han, Yun Liu, Vinod Kumar, Weizhi Xu, Guangze Yang, Chun-Xia Zhao, Trent M. Woodruff, Andrew K. Whittaker, Maree T. Smith |
Abstract: | Ketamine in sub-anaesthetic doses is an analgesic adjuvant with a morphine-sparing effect. Co-administration of a strong opioid with an analgesic adjuvant such as ketamine is a potential treatment option, especially for patients with cancer-related pain. A limitation of ketamine is its short in vivo elimination half-life. Hence, our aim was to develop biocompatible and biodegradable ketamine-loaded poly(ethylene glycol) (PEG)-block-poly (lactic-co-glycolic acid) (PLGA) nanoparticles for sustained release. Ketamine-encapsulated single polymer PEGPLGA nanoparticles and double polymer PEG-PLGA/shellac (SH) nanoparticles with a high drug loading of 41.8% (drug weight/the total weight of drug-loaded nanoparticles) were prepared using a new sequential nanoprecipitation method. These drug-loaded nanoparticles exhibited a sustained-release profile for up to 21 days in vitro and for more than 5 days after intravenous injection in mice. Our study demonstrates that high drug loading and a sustained release profile can be achieved with ketamine-loaded PEG-PLGA nanoparticles prepared using this new nanoprecipitation method. |
Keywords: | Drug delivery High drug loading Pharmacokinetics PLGA Mice |
Rights: | © 2020 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.ijpharm.2020.119291 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1107723 http://purl.org/au-research/grants/arc/LE0775684 http://purl.org/au-research/grants/arc/LE110100028 http://purl.org/au-research/grants/arc/LE110100033 http://purl.org/au-research/grants/arc/LE140100087 http://purl.org/au-research/grants/arc/LE160100168 http://purl.org/au-research/grants/nhmrc/1118881 http://purl.org/au-research/grants/nhmrc/1105420 http://purl.org/au-research/grants/nhmrc/150100798 http://purl.org/au-research/grants/nhmrc/140100726 |
Published version: | http://dx.doi.org/10.1016/j.ijpharm.2020.119291 |
Appears in Collections: | Chemistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.